LINC01116 modulates EMT process via binding with AGO1 mRNA in oesophageal squamous cell carcinoma

被引：3
|
作者：
Fang, Xin [1 ]
Ren, Li-Hua [1 ,2 ]
Shrestha, Sachin Mulmi [1 ]
Ji, Qinghua [2 ]
Xu, Zeyan [1 ]
Wang, Dan [1 ]
Ding, Qitao [1 ]
Liang, Xiao [1 ]
Shi, Rui-hua [1 ,2 ]
机构：
[1] Southeast Univ, Med Coll, Nanjing 210009, Jiangsu, Peoples R China
[2] Southeast Univ, Zhongda Hosp, Dept Gastroenterol, Affiliated Hosp, Nanjing 210009, Jiangsu, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2023年 / 1870卷 / 05期
关键词：
LINC01116; AGO1; Oesophageal squamous cell carcinoma; EMT; CANCER STATISTICS; GASTRIC-CANCER; NONCODING RNAS; PROLIFERATION; PROMOTES; MIGRATION; INVASION; IDENTIFICATION; APOPTOSIS; MORTALITY;
D O I：
10.1016/j.bbamcr.2023.119447
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent researches have uncovered that long non-coding RNAs (lncRNAs) are closely correlated with the development of different diseases, while biological functions and hidden molecular mechanisms of antisense lncRNAs in oesophageal squamous cell carcinoma (OSCC) remain unclear. Here, we identified upregulation of LINC01116 in RNA sequencing data, online database, and in OSCC and intraepithelial neoplasia (IEN) specimens. Functionally, LINC01116 facilitates OSCC advancement and metastasis in vitro and vivo. Mechanistically, elevated expression of LINC01116 in OSCC cells other than tumor stroma and cytoplasmic enables it to activate AGO1 expression via complementary binding with AGO1 mRNA to facilitate EMT process of OSCC.
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页数：14
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