Pt Dendrimer-Encapsulated Nanoparticles Modified UMEAs for Electrochemiluminescence Heterogeneous Immunoassay

被引：0
|
作者：
Hui, Yun [1 ]
Shu, Weiliang [1 ]
Zhu, Jiaxin [2 ]
Li, Jiamei [1 ]
Wu, Tianzhun [1 ]
Zhou, Wenhua [1 ]
Yu, Xuefeng [1 ]
机构：
[1] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China
[2] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA
来源：
2023 IEEE SENSORS | 2023年
基金：
中国国家自然科学基金;
关键词：
Pt Dendrimer-Encapsulated Nanoparticles; ultramicroelectrode array; biomimetic nepenthes peristome structure; Electrochemiluminescence; Heterogeneous Immunoassay;
D O I：
10.1109/SENSORS56945.2023.10325066
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
An open planar microfluidic chip with biomimetic nepenthes peristome structures and integrated ultramicroelectrode arrays (UMEAs) was microfabricated for electrochemiluminescence (ECL) heterogeneous immunoassay. Magnetic beads-based immunocomplex labelled with Ru@SiO2 were prepared for the detection of biomarker proteins. Magnetic beads -based immunocomplex were trapped in microwells developing monodisperse arrays on the surface of UMEAs under curvature-induced laplace pressure. Pt dendrimer encapsulated nanoparticles (Pt-DENs) modified indium tin oxide (ITO) UMEAs exhibited enhanced ECL response and excellent selectivity for the determination of cTnI, which provided new potential for ECL imaging the biomarker protein on a single magnetic bead.
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页数：4
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