Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression

被引：6

作者：

Rocha, Beatriz G. S. ^{[1
]}

Picoli, Caroline C. ^{[1
]}

Goncalves, Bryan O. P. ^{[1
]}

Silva, Walison N. ^{[1
]}

Costa, Alinne C. ^{[1
]}

Moraes, Michele M. ^{[1
]}

Costa, Pedro A. C. ^{[1
]}

Santos, Gabryella S. P. ^{[1
]}

Almeida, Milla R. ^{[1
]}

Silva, Luciana M. ^{[2
]}

Singh, Youvika ^{[3
]}

Falchetti, Marcelo ^{[4
]}

Guardia, Gabriela D. A. ^{[5
]}

Guimaraes, Pedro P. G.

Russo, Remo C. ^{[6
]}

Resende, Rodrigo R. ^{[7
]}

Pinto, Mauro C. X. ^{[8
]}

Amorim, Jaime H. ^{[9
]}

Azevedo, Vasco A. C. ^{[10
]}

Kanashiro, Alexandre ^{[11
]}

Nakaya, Helder I. ^{[3
]}

Rocha, Edroaldo L. ^{[4
]}

Galante, Pedro A. F. ^{[5
]}

Mintz, Akiva ^{[12
]}

Frenette, Paul S. ^{[13
,14
,15
]}

Birbrair, Alexander ^{[1
,11
,12
]}

机构：

[1] Univ Fed Minas Gerais, Dept Pathol, Belo Horizonte, MG, Brazil

[2] Ezequiel Dias Fdn, Dept Cell Biol, Belo Horizonte, MG, Brazil

[3] Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil

[4] Univ Fed Santa Catarina, Dept Microbiol & Immunol, Florianopolis, SC, Brazil

[5] Hosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo, SP, Brazil

[6] Univ Fed Minas Gerais, Dept Physiol & Biophys, Belo Horizonte, MG, Brazil

[7] Univ Fed Minas Gerais, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil

[8] Univ Fed Goias, Inst Biol Sci, Goiania, Go, Brazil

[9] Fed Univ Western Bahia, Ctr Biol Sci & Hlth, Barreiras, BA, Brazil

[10] Univ Fed Minas Gerais, Dept Genet Ecol & Evolut, Belo Horizonte, MG, Brazil

[11] Univ Wisconsin Madison, Med Sci Ctr, Dept Dermatol, 1300 Univ Ave, Madison, WI 53706 USA

[12] Columbia Univ, Dept Radiol, Med Ctr, New York, NY 10027 USA

[13] Albert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, Bronx, NY USA

[14] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY USA

[15] Albert Einstein Coll Med, Dept Med, Bronx, NY USA

来源：

ANGIOGENESIS | 2023年 / 26卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

Tumor microenvironment; Perivascular cells; Glia; Genetic depletion; REGULATORY T-CELLS; ANTITUMOR IMMUNE-RESPONSES; PERIPHERAL NERVOUS-SYSTEM; DIPHTHERIA-TOXIN RECEPTOR; MESENCHYMAL STEM-CELLS; PAIN-RELATED BEHAVIORS; SCHWANN-CELLS; INFILTRATING LYMPHOCYTES; PERIVASCULAR MACROPHAGES; WALLERIAN DEGENERATION;

D O I：

10.1007/s10456-022-09858-1

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Cancer cells are embedded within the tissue and interact dynamically with its components during cancer progression. Understanding the contribution of cellular components within the tumor microenvironment is crucial for the success of therapeutic applications. Here, we reveal the presence of perivascular GFAP+/Plp1+ cells within the tumor microenvironment. Using in vivo inducible Cre/loxP mediated systems, we demonstrated that these cells derive from tissue-resident Schwann cells. Genetic ablation of endogenous Schwann cells slowed down tumor growth and angiogenesis. Schwann cell-specific depletion also induced a boost in the immune surveillance by increasing tumor-infiltrating anti-tumor lymphocytes, while reducing immune-suppressor cells. In humans, a retrospective in silico analysis of tumor biopsies revealed that increased expression of Schwann cell-related genes within melanoma was associated with improved survival. Collectively, our study suggests that Schwann cells regulate tumor progression, indicating that manipulation of Schwann cells may provide a valuable tool to improve cancer patients' outcomes.

引用

页码：129 / 166

页数：38

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