Aminoglycosides in Food: Recent Updates on the Pretreatment and Analysis Methods

Aminoglycosides, as effective, broad-spectrum antibiotics, have been widely used in animal husbandry. These antibiotics can cause potential hazards to human health, as they can accumulate through the food chain. To obtain a better control of food quality and safety, developing effective and sensitive methods for the pretreatment and determination of aminoglycosides is essential. This review aims at elucidating on the health risk-toxicology of aminoglycosides in food and to provide a comprehensive overview of aminoglycosides pretreatment and detection methods since 2010. Moreover, novel pretreatment methods such as microextraction, QuEChERS and online technology as well as novel analytic methods such as orbitrap MS, are summarized. Furthermore, we elaborate and compare the merits and demerits of diverse pretreatment and analytical methods and suggest their future prospects.