Electrochemical Nickel-Catalyzed 1,2-Diarylation of 1,3-Dienes

被引：4

作者：

Chen, Wangzhe ^{[1
]}

Yu, Lei ^{[1
]}

Pan, Yi ^{[1
]}

Ni, Shengyang ^{[1
]}

Wang, Yi ^{[1
]}

机构：

[1] Nanjing Univ, State Key Lab Coordinat Chem, MOE Key Lab High Performance Polymer Mat & Technol, Jiangsu Key Lab Adv Organ Mat,Sch Chem & Chem Engn, Nanjing 210023, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 51期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE 1,2-DIFUNCTIONALIZATION; DIENES; ARYL; ARYLBORATION; DIARYLATION; ALKYLATION; BUTADIENE; HALIDES; OLEFINS;

D O I：

10.1021/acs.orglett.3c03936

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Due to the presence of carbon-carbon double bonds, 1,3-dienes exhibit great reactivity. A protocol for the site-selective diarylation of terminal 1,3-dienes is reported here. The transformation is facilitated by the Ni catalyst without the need for additional ligands, utilizing an electrochemical setup. Preliminary results indicate that by introducing chiral ligands moderate enantioselective diarylation products can be obtained. This method affords diversely substituted diarylated products that occur as structural motifs in various natural products.

引用

页码：9225 / 9230

页数：6

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