The glucose-to-acetate metabolic flux that drives endothelial-to-mesenchymal transition via TGF-β signaling

被引：0
|
作者：
Recatala, Cristina Arce [1 ]
Santoro, Massimo M. [1 ]
机构：
[1] Univ Padua, Dept Biol, Lab Angiogenesis & Canc Metab, I-35131 Padua, Italy
来源：
CELL METABOLISM | 2023年 / 35卷 / 07期
基金：
欧洲研究理事会;
关键词：
HEALTH;
D O I：
10.1016/j.cmet.2023.06.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The metabolic mechanisms supporting the process of endothelial-to-mesenchymal transition (EndMT) remain largely unknown. Here, Zhu et al. describe a novel role for acetate and ACC2 in regulating EndMT and atherosclerosis via modulation of the TGF-beta signaling. This study sheds light on the role of glucose-derived metabolites that drive endothelial pathophysiology.
引用
收藏
页码：1093 / 1095
页数：3
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