Apelin signalling in the periaqueductal grey matter alleviates capsaicin-evoked pulpal nocifensive behaviour and capsaicin-induced spatial learning and memory impairments in rat

被引：3

作者：

Soleimani, Amir Hossein ^{[1
]}

Dehghani, Aghdas ^{[2
]}

Abbasnejad, Mehdi ^{[3
]}

Esmaeili-Mahani, Saeed ^{[3
]}

Raoof, Maryam ^{[4
,5
]}

Lobbezoo, Frank ^{[4
,5
]}

机构：

[1] Hormozgan Univ Med Sci, Fac Med, Dept Physiol, Bandar Abbas, Iran

[2] Hormozgan Univ Med Sci, Endocrinol & Metab Res Ctr, Bandar Abbas, Iran

[3] Shahid Bahonar Univ Kerman, Fac Sci, Dept Biol, Kerman, Iran

[4] Univ Amsterdam, Acad Ctr Dent Amsterdam ACTA, Dept Orofacial Pain & Dysfunct, Gustav Mahlerlaan 3004, NL-1081 LA Amsterdam, Netherlands

[5] Vrije Univ Amsterdam, Gustav Mahlerlaan 3004, NL-1081 LA Amsterdam, Netherlands

来源：

INTERNATIONAL ENDODONTIC JOURNAL | 2023年 / 56卷 / 08期

关键词：

apelinergic system; F13A; learning and memory; opioid receptors; orofacial pain; rats; TRIGEMINAL NUCLEUS CAUDALIS; EXPERIMENTAL TOOTH MOVEMENT; OREXIN; RECEPTOR; OROFACIAL PAIN; EXPRESSION; PROTECTS; LIGAND; MODEL; APJ; GANGLION;

D O I：

10.1111/iej.13930

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

AimPulpal pain is a common orofacial health issue that has been linked to cognitive impairment. Because of its prominent role in pain modulation and cognitive impairment, apelin (Apl) is regarded as a promising target for clinical pain management. The role of Apl in orofacial pain, however, is unknown. The purpose of this study was to determine the effects of intra-periaqueductal grey matter (PAG) administrations of Apl-13 on capsaicin-evoked pulpal nocifensive behaviour and capsaicin-induced spatial learning and memory impairments in rats. MethodologyForty-nine male Wistar rats (200-250 g) were randomly divided into seven groups (n = 7 per group). The groups included: untreated intact, capsaicin (Caps) only, three Caps+Apl groups that received different dosages of intra-PAG injection of Apl-13 (1, 2 and 3 mu g/rat) 20 min prior to capsaicin application, and two Apl+antagonist groups that received Apl receptor antagonist or naloxone (a mu opioid receptor) 20 min before Apl injection. Learning and memory were assessed using the Morris water maze test. One-way analysis of variance followed by Tukey post hoc tests was used for statistical analysis. ResultsIntra-PAG administration of Apl-13 significantly reduced the capsaicin-induced nocifensive behaviour (p < .01). This antinociception effect was inhibited by F13A and naloxone. Apl-13 inhibited nociception-induced learning and memory deficits (p < .01). The cognitive effects were also blocked by pre-treatment administration of F13A (3 mu g/rat). ConclusionsThese findings indicated that Apl-13, via Apl receptors (AR or APJ) and mu opioid receptors, alleviated capsaicin-induced dental nocifensive behaviour and protected against nociception-induced learning and memory impairments. As a result of our findings, Apl appears to be a promising analgesic option for further research in orofacial pain models and clinical trials.

引用

页码：968 / 979

页数：12