Metagenome reveals caprine abomasal microbiota diversity at early and late stages of Haemonchus contortus infection

被引:4
|
作者
Aboshady, Hadeer M. [1 ]
Choury, Alice [2 ]
Montout, Laura [2 ]
Felicite, Yoann [2 ]
Godard, Xavier [3 ]
Bambou, Jean-Christophe [2 ]
机构
[1] Cairo Univ, Fac Agr, Giza, Egypt
[2] INRAE, ASSET, F-97170 Bourg, Guadeloupe, France
[3] INRAE, Plateforme Tropicale Experimentat Anim, F-97170 Petit Bourg, Guadeloupe, France
关键词
PH;
D O I
10.1038/s41598-023-29096-9
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Haemonchus contortus is one of the most detrimental gastrointestinal nematode parasites for small ruminants, especially in tropics and subtropics. Gastrointestinal nematode and microbiota share the same microhabitat; thus they interact with each other and their host. Metagenomics tools provide a promising way to examine the alterations in the gastric microbial composition induces by gastrointestinal parasites. In this study, we used metagenomics tools to characterize the impact of H. contortus infection on the caprine abomasal microbiota at early and late stage of infection and compared it with non-infected control. Our results showed that H. contortus infection caused a significant increase in abomasal pH at early (7 days post-infection) and late stage of infection (56 days post-infection). The analysis of alpha and beta diversity showed that the microbiota diversity both in number and in proportion was significantly affected at early and late stage of infection. All microbiota classes are impacted by H. contortus infection but Clostridia and Bacteroidia are more concerned. In infected animals, the genera Prevotella decreased at 7 and 56 days post-infection. Here we showed that the abomasal microbiota was significantly affected early after H. contortus infection, and these changes persist at late stage of the infection.
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页数:8
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