Molecular effects of polystyrene nanoplastics on human neural stem cells

被引：8
|
作者：
Martin-Folgar, Raquel [1 ]
Gonzalez-Caballero, Ma Carmen [2 ]
Torres-Ruiz, Monica [2 ]
Canas-Portilla, Ana I. [2 ]
Gonzalez, Mercedes de Alba [2 ]
Liste, Isabel [2 ]
Morales, Monica [1 ]
机构：
[1] UNED, Fac Ciencias, Dept Fis Matemat & Fluidos, Grp Biol & Toxicol Ambiental, Las Rozas 28040, Madrid, Spain
[2] Inst Salud Carlos III ISCIII, Environm Toxicol Unit, Inst Salud Carlos ISCIII 3, Majadahonda, Madrid, Spain
来源：
PLOS ONE | 2024年 / 19卷 / 01期
关键词：
HEAT-SHOCK PROTEINS; ALPHA-B-CRYSTALLIN; CYTOCHROME-C-OXIDASE; BCL-X-L; OXIDATIVE DAMAGE; MICROPLASTICS; STRESS; EXPRESSION; EXPOSURE; HSP27;
D O I：
10.1371/journal.pone.0295816
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nanoplastics (NPs) have been found in many ecological environments (aquatic, terrestrial, air). Currently, there is great concern about the exposition and impact on animal health, including humans, because of the effects of ingestion and accumulation of these nanomaterials (NMs) in aquatic organisms and their incorporation into the food chain. NPs ' mechanisms of action on humans are currently unknown. In this study, we evaluated the altered molecular mechanisms on human neural stem cell line (hNS1) after 4 days of exposure to 30 nm polystyrene (PS) NPs (0.5, 2.5 and 10 mu g/mL). Our results showed that NPs can induce oxidative stress, cellular stress, DNA damage, alterations in inflammatory response, and apoptosis, which could lead to tissue damage and neurodevelopmental diseases.
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页数：19
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