Neonatal Seizure Pattern, Outcome, and its Predictors Among Neonates Admitted to NICU of Ayder Comprehensive Specialized Hospital Mekelle, Tigray, Ethiopia

被引:1
|
作者
Weldegerima, Kiros [1 ]
Gebremariam, Dawit Seyoum [1 ,3 ]
Haftu, Hansa [1 ]
Berhe, Gebretsadik [2 ]
Hadgu, Amanuel [1 ]
Mohammedamin, Mohammed Mustefa [1 ]
机构
[1] Mekelle Univ, Coll Hlth Sci, Sch Med, Dept Pediat & Child Hlth, Mekelle, Ethiopia
[2] Mekelle Univ, Coll Hlth Sci, Sch Publ Hlth, Dept Epidemiol, Mekelle, Ethiopia
[3] Mekelle Univ, Coll Hlth Sci, Sch Med, Dept Pediat & Child Hlth, POB 1871, Mekelle, Ethiopia
关键词
neonatal seizure; pattern; outcome; predictors;
D O I
10.2147/IJGM.S414420
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Seizure is the most frequently observed symptom of neurological disorders and an important determinant of outcome during neonatal period. In clinical practice, it is prevalent and observed in neonates admitted to hospital in low-resources countries, but due to the paucity of studies in these regions, little is known about its pattern, clinical outcomes of hospitalization, and its predictors. Therefore, aims to evaluate seizure patterns, clinical outcomes, and its predictors among neonates admitted to the NICU of ACSH, Mekelle, and Tigray.Methods: A hospital-based cross-sectional study design was conducted among neonates with neonatal seizures admitted to NICU of Ayder Comprehensive Specialized Hospital. Data collection was done from record reviews. SPSS Version 25 was used. Descriptive statistics and bivariate logistic regressions where a p-value of <0.05 is considered statistically significant.Results: Out of 1622 NICU admissions, 155 (9.6%) were cases of neonatal seizure. The most frequently observed types of seizure in this study were subtle 70 (45.1%) and tonic 49 (31.6%) respectively. At the end of hospitalization 70.3% of neonates were discharged improved, 21.3% of neonates died and 8.4% of neonates had severe neurologic deficits. Poorly controlled seizures (AOR 4.8, 95% CI 2.6-9.2), prolonged duration of labor (AOR 4.3, 95% CI 2.2-8.8) and seizure onset <72 hours (AOR 3.7, 95% CI 1.6-8.5), respectively, were found to be independent predictors of poor neonatal outcome.Conclusion: Of all neonatal admissions, neonatal seizure was observed in close to 9.6%. The most frequently observed type of seizure was subtle. Of those admitted neonates, 30% had poor outcomes following the end of their hospitalization or when they leave against medical advice for lack of improvement). Poorly controlled seizures, prolonged duration of labor, and seizure onset <72 hours were independent predictors of poor neonatal outcomes.
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页数:13
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