Secondary metabolites from Pseudallescheria boydii and their anti-melanoma activity

被引：0

作者：

Qin, Su-Lu ^{[1
]}

Ding, Jia-Xin ^{[1
]}

Huang, Cheng-Yun ^{[1
]}

Li, Jing ^{[1
]}

Yao, Ming ^{[1
]}

Liu, Qing-Pei ^{[1
]}

Wang, Wen-Jing ^{[1
]}

Yang, Xiao-Long ^{[1
]}

机构：

[1] South Cent Minzu Univ, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China

来源：

TETRAHEDRON | 2023年 / 147卷

基金：

中国国家自然科学基金;

关键词：

Pseudallescheria boydii; beta-carboline alkaloids; Asperitaconic acid; Cyclotetrapeptide; Anti -melanoma activity; Network pharmacology; METASTATIC MELANOMA; CONSTITUENTS; AGENTS;

D O I：

10.1016/j.tet.2023.133663

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new asperitaconic acid (1) and an undescribe cyclotetrapeptide (2), together with nine known compounds (3-11), were isolated from the endophytic fungus Pseudallescheria boydii XL-0256 obtained from the leaves of Dimocarpus longan Lour. The structures of the new compounds have been successfully assigned based on the NMR spectroscopic data and the mass spectrometric analysis. Compound 3 was confirmed to significantly reduce B16-F10 cell viability in a dose- and time-dependent manner, as well as promoting cell apoptosis and inhibiting cell migration in B16-F10 cell. In addition, compound 3 was hypothesized to have an anti-melanoma effect through target proteins (ADAM17 and ADAMTS5) based on network pharmacological target prediction and molecular docking studies.

引用

页数：8

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