Continuous flow process development for the synthesis of an industrial raw material via solvent-free aromatic Claisen rearrangement

被引：1
|
作者：
Petrovic, Nikola [1 ,2 ]
Otvos, Sandor B. [1 ,2 ]
Kappe, C. Oliver [1 ,2 ]
机构：
[1] Res Ctr Pharmaceut Engn GmbH RCPE, Ctr Continuous Flow Synth & Proc CCFLOW, Inffeldgasse 13, A-8010 Graz, Austria
[2] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, Heinrichstr 28, A-8010 Graz, Austria
来源：
JOURNAL OF FLOW CHEMISTRY | 2023年 / 13卷 / 04期
关键词：
Claisen rearrangement; Coil reactor; Continuous flow; Solvent-free conditions; PROCESS WINDOWS; MICROWAVE REACTOR; HIGH-TEMPERATURE; BENZOXAZINE; CHEMISTRY;
D O I：
10.1007/s41981-023-00275-z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A high-temperature continuous flow protocol is reported for the intensified synthesis of an important industrial raw material via aromatic Claisen rearrangement of the corresponding diallyl ether precursor. The process takes advantage of solvent-free conditions, thereby maximizing productivity whilst reducing cost and environmental impact. By precise control over reaction temperature and residence times, a high-yielding and selective synthesis is achieved that ensures improved safety and scalability of the exothermic transformation compared with earlier batch methodologies.
引用
收藏
页码：443 / 447
页数：5
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