Visible-light-driven C(sp3)-H alkylation of heterobenzylic amines via electron donor-acceptor complexes

被引：4
|
作者：
Huo, Yumei [1 ]
Chen, Beibei [1 ]
Xu, Zhaoqing [1 ,2 ]
Ren, Xiaoyu [1 ]
Qi, Rupeng [1 ]
Wang, Chao [1 ,2 ]
机构：
[1] Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China
[2] Chinese Acad Med Sci, Res Unit Peptide Sci, 2019RU066, Lanzhou 730000, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2023年 / 11卷 / 01期
基金：
中国博士后科学基金;
关键词：
D O I：
10.1039/d3qo01765f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Heterobenzylic amines such as alpha-alkyl- substituted oxadiazole methylamine skeletons present as essential motifs in pharmaceuticals and pesticides, due to their unique biological activities. Photoredox reactions mediated by electron donor-acceptor (EDA) complexes are relatively environmentally friendly, and have attracted much attention in current organic synthesis research. Herein, we report a C-H alkylation of heterobenzylic amines under visible light irradiation, involving an EDA complex formed upon association of alkyl iodide and organophosphines in catalytic amounts.
引用
收藏
页码：205 / 210
页数：6
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