Image processing-based online analysis and feedback control system for droplet dripping process

被引:1
|
作者
Chen, Hang [1 ]
Tian, Ying [1 ]
Zhang, Sheng [1 ]
Wang, Xiaoping [1 ]
Qu, Haibin [1 ]
机构
[1] Zhejiang Univ, Pharmaceut Informat Inst, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China
关键词
Droplet quality control; Image processing; Dripping pills; Process analytical technology; Feedback control; PAT TOOL; TECHNOLOGY; SPECTROSCOPY; PILL;
D O I
10.1016/j.ijpharm.2023.123736
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Droplets find wide application across diverse industries, where maintaining their quality is paramount. Precise control over the substance content within droplets demands non-destructive and online analysis techniques, such as Process Analytical Technology (PAT), often integrated with control strategies. In this context, the present study focuses on the example of controlling droplet quality during the dripping process of pills. Leveraging the dripping and image acquisition systems established in previous research, a novel feedback control system centered on image processing was devised for the quality control of dripping pills. The system was developed and its efficacy was assessed, yielding satisfactory outcomes. The proposed system facilitates real-time monitoring of pill weight through the analysis of droplet images during the dripping process, thereby offering real-time feedback control of pill weight. Importantly, this system holds potential for broader applications beyond the scope of this study.
引用
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页数:14
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