Bidentate Lewis Acid-Catalyzed Inverse Electron-Demand Diels-Alder Reaction of Phthalazines and Cyclooctynes

被引：0
|
作者：
Grosse, Michel [1 ,2 ]
Wegner, Hermann A. [1 ,2 ]
机构：
[1] Justus Liebig Univ, Inst Organ Chem, Heinrich Buff Ring 17, D-35392 Giessen, Germany
[2] Justus Liebig Univ, Ctr Mat Res LaMa ZfM, Heinrich Buff Ring 16, D-35392 Giessen, Germany
来源：
SYNLETT | 2024年 / 35卷 / 09期
关键词：
cycloaddition; diazines; cyclooctyne; bidentate catalysis; polycyclic aromatic hydrocarbons; Diels-Alder reactions; CYCLOADDITION REACTIONS; 1,2-DIAZINES; TETRAZINE; 1,2,4,5-TETRAZINE; FUNCTIONALIZATION; BICYCLONONYNES; LIGATION;
D O I：
10.1055/a-2204-9522
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we report a method for facilitating the inverse-electron-demand Diels-Alder reaction of 1,2-diazines and cyclooctynes by utilizing a boron-based bidentate Lewis acid catalyst. Readily available electron-deficient and electron-rich phthalazines proved to be suitable substrates in this transformation. The described method enables the facile construction of diversely substituted polycyclic aromatic hydrocarbons fused to eight-membered carbocycles.
引用
收藏
页码：1019 / 1022
页数：4
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