Mitochondrial transplantation: an overview of a promising therapeutic approach

Mitochondrial transplantation is a promising therapeutic approach for the treatment of mitochondrial diseases caused by mutations in mitochondrial DNA, as well as several metabolic and neuro-logical disorders. Animal studies have shown that mitochond-rial transplantation can improve cellular energy metabolism, re-store mitochondrial function, and prevent cell death. However, challenges need to be addressed, such as the delivery of func-tional mitochondria to the correct cells in the body, and the long-term stability and function of the transplanted mitochond-ria. Researchers are exploring new methods for mitochondrial transplantation, including the use of nanoparticles or CRISPR gene editing. Mechanisms underlying the integration and function of transplanted mitochondria are complex and not fully under-stood, but research has revealed some key factors that play a role. While the safety and efficacy of mitochondrial transplan-tation have been investigated in animal models and human trials, more research is needed to optimize delivery methods and eval-uate long-term safety and efficacy. Clinical trials using mitochond-rial transplantation have shown mixed results, highlighting the need for further research in this area. In conclusion, although mitochondrial transplantation holds significant potential for the treatment of various diseases, more work is needed to overcome challenges and evaluate its safety and efficacy in human trials.