Atropine-eluting silicone contact lenses for myopia control

被引:3
|
作者
Fu, Yan [1 ,2 ]
Luo, Yang [1 ,2 ]
Chen, Xi [1 ]
Tong, Yao [1 ,2 ]
Zhu, Yabin [2 ,3 ]
Yang, Lu [1 ,2 ]
机构
[1] Ningbo Univ, Affiliated Hosp, Med Sch, Ningbo, Peoples R China
[2] Ningbo Univ, Sch Med, Ningbo, Peoples R China
[3] Ningbo Univ, Sch Med, 818 Fenghua Rd, Ningbo 315211, Zhejiang, Peoples R China
关键词
Myopia; atropine; contact lenses; implantation; guinea pig; IN-VIVO EVALUATION; DRUG-DELIVERY; WATER-CONTENT; VITRO; RELEASE; ALBUMIN;
D O I
10.1177/08853282231166858
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Myopia, also known as nearsightedness, is one of the prime reasons for vision impairment worldwide. Atropine in topical ophthalmic solutions (e.g., 0.01% atropine sulfate eye drops) is the primary medical treatment for controlling myopia, especially for pseudomyopia or true myopia in rapid progress. However, aqueous atropine solution is unstable and easily breaks down to tropic acid, which will result in vision blur. Drug-eluting contact lenses (CLs) have been explored as a potentially superior alternative to effectively control the drug release and improve the drug efficacy. In this work, an atropine-eluting contact lens was developed by encapsulating an atropine implant in a silicon-based contact lens, towards functioning in vision correction and controlling myopia. The safety and effectiveness of this atropine-eluting contact lens were verified with rabbit and guinea pig models. The results showed that the lenses reduced the side effects like mydriasis and no other adverse events were observed in rabbit eyes. More importantly, atropine-loaded lenses could effectively delay the progress of form-deprivation myopia with guinea pig eyes as the model. Thus, we concluded that atropine-eluting CLs prepared by implantation technology may be an option for the treatment of myopia.
引用
收藏
页码:1724 / 1735
页数:12
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