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Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth,Sch Biol Sci, Ctr Epidemiol Versus Arthrit,Div Musculoskeletal, Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth,Sch Biol Sci, Ctr Epidemiol Versus Arthrit,Div Musculoskeletal, Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England