Synthesis of pyrido[1,2-a]indol-6(7H)-ones via a visible light-photocatalyzed formal (4+2) cycloaddition of indole-derived bromides and alkenes or alkynes

被引：4
|
作者：
Wei, Minghui [1 ]
Liu, Chengkou [1 ]
Wang, Chang-Sheng [1 ]
Li, Yuguang [4 ]
Qiu, Peng [5 ]
Dong, Quanxiao [5 ]
Yang, Zhao [2 ]
Fang, Zheng [1 ]
Guo, Kai [1 ,3 ]
机构：
[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 Puzhu Rd S, Nanjing 211816, Peoples R China
[2] China Pharmaceut Univ, Coll Engn, 24 Tongjiaxiang, Nanjing 210003, Peoples R China
[3] State Key Lab Mat Oriented Chem Engn, 30 Puzhu Rd S, Nanjing 211816, Peoples R China
[4] Jiangsu Ind Technol Res Inst, Biol & Med Dept, Nanjing 210031, Peoples R China
[5] Hebei Tieke Yichen New Mat Technol Co Ltd, Shijiazhuang 052160, Hebei, Peoples R China
来源：
GREEN CHEMISTRY | 2023年 / 25卷 / 06期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
EFFICIENT SYNTHESIS; TERTIARY-AMINES; OXIME; RADICALS; STRATEGY;
D O I：
10.1039/d2gc04491a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We successfully developed an unprecedented synthesis route to pyrido[1,2-a]indol-6(7H)-ones through a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes in a microchannel reactor. This novel protocol features extremely mild conditions, a broad substrate scope and high reaction efficiency. In addition, a reasonable reaction mechanism based on controlled experiments was proposed.
引用
收藏
页码：2453 / 2457
页数：5
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