In-vitro release studies of ciprofloxacin drug using polyaniline/polypyrrole-encapsulated β-cyclodextrin nanocomposites

被引：2
|
作者：
Zia, Jannatun [2 ]
Riyazuddin, Mohd [2 ]
Jackson, Shaila [1 ]
Taylor, Darlene K. [1 ]
Riaz, Ufana [1 ,2 ]
机构：
[1] North Carolina Cent Univ, Dept Chem & Biochem, Durham, NC 27707 USA
[2] Jamia Millia Islamia, Dept Chem, Mat Res Lab, New Delhi 110025, India
来源：
POLYMER BULLETIN | 2023年 / 80卷 / 12期
基金：
美国国家科学基金会;
关键词：
Polyaniline; Polypyrrole; beta-cyclodextrin; Ciprofloxacin; Adsorption; Drug release kinetics; ONE-POT SYNTHESIS; CONDUCTING POLYMER; POLYPYRROLE; DELIVERY; NANOPARTICLES; NANOHYBRIDS; DEGRADATION; POLYANILINE;
D O I：
10.1007/s00289-022-04667-4
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The present study reports the synthesis of nanocomposites of beta-cyclodextrin (beta-CD) with polyaniline (PANI) and polypyrrole (PPy) to design core-shell nanocomposites. The synthesized nanocomposites were investigated for their spectral, morphological and thermal characteristics. IR spectra confirmed the incorporation of PANI and PPy in beta-CD by the strong interaction between NH of PANI/PPY and OH of beta-CD, while the ultraviolet (UV)-visible spectra confirmed the polaronic state of conducting polymers in the nanocomposites. The scanning electron microscopy (SEM) analysis revealed the core-shell like morphology of the nanocomposites. Ciprofloxacin (CIP) was chosen as a model drug to study the in-vitro drug release as gastric (pH 1.2) and intestinal (pH 7.4) values by loading the drug (50 mg) into the pristine polymers as well as beta-CD nanocomposites. The nanocomposites were found to show the sustained release behavior and hold potential to be used as an effective antibiotic drug delivery vehicle.
引用
收藏
页码：12557 / 12576
页数：20
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