Red Cell Distribution Width Association with Subclinical Cardiovascular Disease in Patients with Rheumatoid Arthritis

被引:2
|
作者
Gonzalez-Sierra, Marta [1 ]
Romo-Cordero, Alejandro [2 ]
Quevedo-Abeledo, Juan C. [3 ]
Quevedo-Rodriguez, Adrian [3 ]
Gomez-Bernal, Fuensanta [4 ]
de Vera-Gonzalez, Antonia [4 ]
Lopez-Mejias, Raquel [5 ]
Martin-Gonzalez, Candelaria [2 ,6 ]
Gonzalez-Gay, Miguel Angel [7 ,8 ]
Ferraz-Amaro, Ivan [6 ,9 ]
机构
[1] Hosp Univ Canarias, Div Hospitalizat At Home, Tenerife 38320, Spain
[2] Hosp Univ Canarias, Div Internal Med, Tenerife 38320, Spain
[3] Hosp Univ Dr Negrin, Div Rheumatol, Las Palmas Gran Canaria 35010, Spain
[4] Hosp Univ Canarias, Div Cent Lab, Tenerife 38320, Spain
[5] Hosp Univ Marques Valdecilla, Inst Invest Sanitaria Marques Valdecilla IDIVAL, Epidemiol Genet & Atherosclerosis Res Grp Syst In, Santander 39011, Spain
[6] Univ La Laguna, Internal Med Dept, Tenerife 38200, Spain
[7] Univ Cantabria, Dept Med & Psychiat, Santander 39005, Spain
[8] IIS Fdn Jimenez Diaz, Div Rheumatol, Madrid 28040, Spain
[9] Hosp Univ Canarias, Div Rheumatol, Tenerife 38320, Spain
关键词
rheumatoid arthritis; red cell distribution width; cardiovascular disease; SCORE2; ACTIVITY INDEX; RISK; MORTALITY; INFLAMMATION; CRITERIA; ANEMIA; RDW;
D O I
10.3390/jcm12206497
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Red cell distribution width (RDW) is a measure of the variation in mean corpuscular volume that reflects the degree of anisocytosis on the peripheral blood smear. RDW value variation has been implicated in several disorders including chronic inflammatory processes and cardiovascular (CV) diseases. In the present work, our objective was to study the relationship that RDW has with the characteristics of the disease in patients with rheumatoid arthritis (RA), focusing on CV risk factors and subclinical atherosclerosis. A cross-sectional study was conducted that included 430 patients with RA and 208 controls matched by sex and age. Complete blood count, including RDW, was assessed. Multivariable analysis was performed to analyze the relationship of RDW with RA disease characteristics, subclinical carotid atherosclerosis, and traditional CV factors, including a comprehensive profile of lipid molecules and insulin resistance and beta cell function indices. After multivariable adjustment, the RDW was significantly higher in RA patients compared with controls (beta coefficient 1.0 [95% confidence interval 0.2 to 1.8] %, p = 0.020). Furthermore, although the erythrocyte sedimentation rate showed a positive and significant relationship with RDW, this association was not found with C-reactive protein and interleukin-6. A positive and independent relationship was observed between DAS28-ESR disease activity score and RDW. However, no association was found between the RDW and other disease activity scores that do not include erythrocyte sedimentation rate in their formula. The SCORE2 CV risk algorithm was positively and significantly associated with higher RDW values. Likewise, a negative relationship was found between RDW with total cholesterol and low-density lipoprotein cholesterol, and a positive relationship was found between RDW and insulin resistance indices. In conclusion, RDW values are higher in RA patients compared to matched controls. Although the relationship of RDW with disease activity was not consistent, RDW shows associations with subclinical CV disease risk factors, including dyslipidemia and insulin resistance, and with the SCORE2 CV disease-risk prediction algorithm.
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页数:12
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