Puniceusinene and puniceusoacids A-B, three novel dimmers from Streptomyces puniceus D-4

被引：0

作者：

Guo, Zhi-Yong ^{[1
,2
]}

He, Ying ^{[1
]}

Song, Wen-Min ^{[1
]}

Tang, Guan-Mei ^{[1
]}

Kong, De-Shuai ^{[1
]}

Zhang, Xue-Qing ^{[1
,2
]}

Proksch, Peter ^{[3
]}

机构：

[1] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China

[2] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Key Lab Funct Yeast, China Natl Light Ind, Yichang 443002, Peoples R China

[3] Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany

来源：

TETRAHEDRON LETTERS | 2023年 / 121卷

基金：

中国国家自然科学基金;

关键词：

Polyene dimer; Puniceusinene; Puniceusoacid; Streptomyces puniceus; Antimicrobial activity; EXCITED-STATES;

D O I：

10.1016/j.tetlet.2023.154487

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel keyring-like no-heteroatom polyene dimer, puniceusinene (1), and two new N-N linking pattern dimers, puniceusoacids A (2) and B (3), together with seven known metabolites (4-10), were isolated from Streptomyces puniceus D-4 derived from garlic. The structures of compounds 1-3 were elucidated by comprehensive spectroscopic analysis. Compound 1 exhibited inhibitory activity against Candida albi-cans with an MIC value of 38.4 lg/mL. Compounds 6-8 displayed antibacterial activity against five strains of pathogenic bacteria with MIC values ranging from 8.3 to 45.3 lg/mL. (c) 2023 Elsevier Ltd. All rights reserved.

引用

页数：5

共 33 条

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