The Inconsistent Assessment of Quality of Life in Patients Treated for Head and Neck Cancer with Anti-EGFR Inhibitors: A Systematic Scoping Review

被引：0
|
作者：
Sutton, Sarah R. [1 ,2 ]
Taniguchi, April N. [1 ]
Nguyen, Shaun A. [1 ]
Albergotti, William G. [1 ]
Kaczmar, John M. [3 ]
Kejner, Alexandra E. [1 ]
Newman, Jason G. [1 ]
机构：
[1] Med Univ South Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA
[2] Univ Nevada, Sch Med, Reno, NV 89557 USA
[3] Med Univ South Carolina, Div Hematol & Oncol, Charleston, SC 29425 USA
来源：
CANCERS | 2023年 / 15卷 / 09期
关键词：
anti-EGFR inhibitors; head and neck cancer; quality of life; SQUAMOUS-CELL CARCINOMA; LOCALLY ADVANCED HEAD; THERAPY LUX-HEAD; RADIATION-THERAPY; PHASE-II; EUROPEAN-ORGANIZATION; FUNCTIONAL ASSESSMENT; EORTC QLQ-H-AND-N35; 2ND-LINE TREATMENT; PERFORMANCE STATUS;
D O I：
10.3390/cancers15092475
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In patients receiving treatment for head and neck cancer (HNC), there is a correlation between quality of life (QoL) scores and treatment outcomes. Higher QoL scores have been associated with improved survival. Despite this, the assessment of QoL in clinical trials varies considerably. Three databases (Scopus, PubMed, and Cinahl) were queried for articles published in English between 2006 and 2022. Two reviewers (SRS and ANT) performed study screening, data extraction, and risk of bias assessment. The authors identified 21 articles that met the inclusion criteria. A total of 5961 patients were evaluated. QoL was reported as average scores for specific variables across five different surveys in 12 included articles. Supplemental QoL data were available in 10 included studies. Critical appraisal of studies indicated a high risk of bias due to the inclusion of trials. There is no standard method for reporting QoL data in clinical trials for HNC patients undergoing treatment with antiEGFR inhibitors. Future clinical trials should standardize their method for assessing and reporting quality-of-life data to increase patient-centered care and refine treatment choices to optimize survival.
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页数：14
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