Bioinspired Total Synthesis of (+)-Kopsiyunnanine B

被引：0

作者：

Imaoka, Sho ^{[1
]}

Nakashima, Yuta ^{[1
]}

Kitajima, Mariko ^{[1
]}

Ishikawa, Hayato ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, 1-8-1 Inohana,Chuo Ku, Chiba 2608675, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2024年 / 72卷 / 01期

关键词：

bioinspired reaction; total synthesis; oxindole alkaloid; cascade reaction; Kopsia alkaloid; INDOLE ALKALOIDS; RECENT PROGRESS; CHEMISTRY;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The first enantioselective total synthesis of kopsiyunnanine B, which has a unique folded and complex pentacyclic structure containing six contiguous chiral centers, has been achieved along our originally proposed biosynthetic pathway. The key reaction of this synthesis includes a bioinspired cascade that builds three ring structures and three chiral centers in one step and features the stereoselective reduction of a beta-acrylate and oxidation to an oxindole.

引用

页码：68 / 74

页数：7

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