Phase Separation of PML/RARa Microspeckles Governs Transcriptional Dysregulation through Genomic Rewiring of BRD4 in Acute Promyelocytic Leukemia

被引：0

作者：

Zhang, Yi ^{[1
]}

Wang, Kankan ^{[2
,3
]}

Lou, Jiacheng ^{[4
]}

Liu, Yabin ^{[5
]}

Jin, Peng ^{[4
]}

Tan, Yun ^{[4
]}

Song, Huan ^{[6
]}

Jin, Wen ^{[2
]}

Dong, Fangyi ^{[2
]}

Wu, Shishuang ^{[4
]}

Fang, Hai ^{[5
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Inst Hematol, Ruijin Hosp, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Inst Hematol,Natl Res Ctr Translat Med, Sch Med,State Key Lab Med Gen, Ruijin Hosp, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Hematol, Ruijin Hosp, Shanghai, Peoples R China

[5] Shanghai Inst Hematol, State Key Lab Med Genom, Shanghai, Peoples R China

[6] Shanghai Jiao Tong Univ, Shanghai Inst Hematol, Ruijin Hosp, Shanghai, Peoples R China

来源：

BLOOD | 2023年 / 142卷

关键词：

D O I：

10.1182/blood-2023-180510

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：3

共 33 条

[1] Phase separation of PML/RARα and BRD4 coassembled microspeckles governs transcriptional dysregulation in acute promyelocytic leukemia
Zhang, Yi
Lou, Jiacheng
Liu, Yabin
Jin, Peng
Tan, Yun
Song, Huan
Jin, Wen
Wang, Dan
Dong, Fangyi
Wu, Shishuang
Fang, Hai
Chen, Saijuan
Chen, Zhu
Wang, Kankan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 121 (34)
[2] BRD4 interacts with PML/RAR in acute promyelocytic leukemia
Luo, Qun
Deng, Wanglong
Wang, Haiwei
Fan, Huiyong
Zhang, Ji
FRONTIERS OF MEDICINE, 2018, 12 (06) : 726 - 734
[3] BRD4 interacts with PML/RARα in acute promyelocytic leukemia
Qun Luo
Wanglong Deng
Haiwei Wang
Huiyong Fan
Ji Zhang
Frontiers of Medicine, 2018, 12 : 726 - 734
[4] The Essential Transcriptional Function of BRD4 in Acute Myeloid Leukemia
Roe, Jae-Seok
Vakoc, Christopher R.
TARGETING CANCER, VOL 81, 2016, 2016, 81 : 61 - 66
[5] Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
Nasr, Rihab
Guillemin, Marie-Claude
Rousselot, Philippe
de The, Hugues
HEMATOLOGIE, 2009, 15 (01): : 15 - 18
[6] Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
Rihab Nasr
Marie-Claude Guillemin
Omar Ferhi
Hassan Soilihi
Laurent Peres
Caroline Berthier
Philippe Rousselot
Macarena Robledo-Sarmiento
Valérie Lallemand-Breitenbach
Bernard Gourmel
Dominique Vitoux
Pier Paolo Pandolfi
Cécile Rochette-Egly
Jun Zhu
Hugues de Thé
Nature Medicine, 2008, 14 : 1333 - 1342
[7] Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
Nasr, Rihab
Guillemin, Marie-Claude
Ferhi, Omar
Soilihi, Hassan
Peres, Laurent
Berthier, Caroline
Rousselot, Philippe
Robledo-Sarmiento, Macarena
Lallemand-Breitenbach, Valerie
Gourmel, Bernard
Vitoux, Dominique
Pandolfi, Pier Paolo
Rochette-Egly, Cecile
Zhu, Jun
de The, Hugues
NATURE MEDICINE, 2008, 14 (12) : 1333 - 1342
[8] PML/RARa blocks the differentiation and promotes the proliferation of acute promyelocytic leukemia through activating MYB expression by transcriptional and epigenetic regulation mechanisms
Wang, Genjie
Tian, Ying
Hu, Qingzhu
Xiao, Xichun
Chen, Shuxia
JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (02) : 1210 - 1220
[9] Acute Promyelocytic Leukemia with a Rare PML Exon 4/RARA Exon 3 Fusion Transcript Variant
Oh, Se Jin
Park, The Sung
Lee, Jin Young
Mun, Yeung Chul
Seong, Chu Myong
Marschalek, Rolf
Meyer, Claus
Chung, Wha Soon
Huh, Jungwon
ACTA HAEMATOLOGICA, 2013, 130 (03) : 176 - 180
[10] The arsenic-based cure of acute promyelocytic leukemia promotes cytoplasmic sequestration of PML and PML/RARA through inhibition of PML body recycling
Lang, Emma
Grudic, Amra
Pankiv, Serhiy
Bruserud, Oystein
Simonsen, Anne
Bjerkvig, Rolf
Bjoras, Magnar
Boe, Stig Ove
BLOOD, 2012, 120 (04) : 847 - 857

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