Low-Dose Immune Tolerance Induction Therapy for Severe Hemophilia a Inhibitor Patients: Immunosuppressants Improve Outcomes but Are Generally Not Necessary for Inhibitor-Titer below 200 BU/Ml

被引:0
|
作者
Li, Zhengping [1 ]
Poon, Man-Chiu [2 ]
Wu, Runhui [1 ]
机构
[1] Capital Med Univ, Beijing Childrens Hosp, Hematol Dept, Beijing, Peoples R China
[2] Univ Calgary, Calgary, AB, Canada
关键词
D O I
10.1182/blood-2023-184514
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:4
相关论文
共 16 条
  • [1] Low-dose immune tolerance induction for severe hemophilia A inhibitor patients: Immunosuppressants are generally not necessary for inhibitor-titer below 200 BU/mL
    Li Zhengping
    Sun Jie
    Li Zekun
    Chen Zhenping
    Liu Guoqing
    Yao Wanru
    Cheng Xiaoling
    Li Gang
    Zhen Yingzi
    Ai Di
    Zhou Yaohan
    Mao Qianqian
    Poon ManChiu
    Wu Runhui
    儿科学研究(英文), 2024, 08 (02)
  • [2] Low-dose immune tolerance induction for severe hemophilia A inhibitor patients: Immunosuppressants are generally not necessary for inhibitor-titer below 200 BU/mL
    Li, Zhengping
    Sun, Jie
    Li, Zekun
    Chen, Zhenping
    Liu, Guoqing
    Yao, Wanru
    Cheng, Xiaoling
    Li, Gang
    Zhen, Yingzi
    Ai, Di
    Zhou, Yaohan
    Mao, Qianqian
    Poon, Man-Chiu
    Wu, Runhui
    PEDIATRIC INVESTIGATION, 2024, 8 (02) : 91 - 100
  • [3] LOW-DOSE IMMUNE TOLERANCE INDUCTION THERAPY IN SEVERE HEMOPHILIA A CHILDREN WITH HIGH-TITER INHIBITOR
    Elalfy, M. S.
    Elghamry, I.
    Hassab, H.
    Elalfy, O.
    Andrawes, N. G.
    El-Ekiaby, M.
    HAEMOPHILIA, 2021, 27 : 97 - 97
  • [4] Low-dose immune tolerance induction therapy in severe hemophilia a children in China: Starting earlier resulted in better inhibitor eradication outcomes
    Li, Zhengping
    Sun, Jie
    Li, Zekun
    Chen, Zhenping
    Liu, Guoqing
    Yao, Wanru
    Li, Gang
    Zhen, Yingzi
    Cheng, Xiaoling
    Ai, Di
    Huang, Kun
    Poon, Man-Chiu
    Wu, Runhui
    THROMBOSIS RESEARCH, 2023, 225 : 33 - 38
  • [5] Shorter Time Interval from Inhibitor Detection to Starting Low-Dose Immune Tolerance Induction Therapy Is Associated with Better Inhibitor Eradication Outcomes in Severe Hemophilia a Children with High-Titer Inhibitors in China
    Li, Zhengping
    Poon, Man-Chiu
    Liu, Guoqing
    Li, Zekun
    Sun, Jie
    Wu, Runhui
    BLOOD, 2022, 140 : 2757 - 2758
  • [6] Immune Tolerance Induction with High-Dose FVIII and Combined Immunosuppressive Therapy in a Patient with Severe Hemophilia A and High-Titer Inhibitor
    Ranta, S.
    Petrini, P.
    HAEMOPHILIA, 2016, 22 : 95 - 95
  • [7] Prophylactic treatment and Rituximab subsequent immune tolerance induction therapy to improve inhibitor eradication on resistant ITI in severe hemophilia A patients with inhibitor
    Chen, Yeu-Chin
    Cheng, Shin-Nan
    HAEMOPHILIA, 2016, 22 : 69 - 69
  • [8] Successful inhibitor eradication for hemophilia A children with poor-risk high-titer inhibitor using low-dose immune-tolerance induction strategy
    Li, Zekun
    Chen, Zhenping
    Cheng, Xiaoling
    Wu, Xinyi
    Li, Gang
    Zhen, Yingzi
    Cai, Siyu
    Poon, Man-Chiu
    Wu, Runhui
    HAEMOPHILIA, 2020, 26 : 33 - 34
  • [9] Prophylactic treatment with FEIBA and subsequent immune tolerance induction therapy to improve inhibitor eradication on hemophilia A patients with inhibitor
    Chien, S.
    Chen, Y.
    HAEMOPHILIA, 2010, 16 : 70 - 70
  • [10] Low-dose immune tolerance induction in children with severe hemophilia A with high-titer inhibitors: Type of factor 8 mutation and outcomes
    Sun, Jie
    Li, Zekun
    Li, Gang
    Huang, Kun
    Ai, Di
    Liu, Guoqing
    Yao, Wanru
    Xie, Xingjuan
    Gu, Hao
    Zhen, Yingzi
    Chen, Zhenping
    Wu, Runhui
    RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, 2022, 6 (07)