Interleukin-33 as a Potential Therapeutic Target in Gastric Cancer Patients: Current Insights

被引:2
|
作者
Chatterjee, Annesha [1 ]
Tins, Jordana Maria Azevedo-Mar [1 ]
Stachler, Matthew D. [1 ,2 ]
机构
[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, 513 Parnassus Ave HSW450B, San Francisco, CA 94143 USA
来源
ONCOTARGETS AND THERAPY | 2023年 / 16卷
关键词
gastric cancer; interleukin-33; therapeutic target; ST2; GENE-PRODUCT; POLYPEPTIDE-EXPRESSING METAPLASIA; INHIBITS TUMOR-GROWTH; HUMAN LUNG-CANCER; VARIANT FORM; COLORECTAL-CANCER; IL-33/ST2; PATHWAY; BREAST-CANCER; UP-REGULATION; CD8(+) T;
D O I
10.2147/OTT.S389120
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Gastric cancer is a significant global health problem as it is the fifth most prevalent cancer worldwide and the fourth leading cause of cancer-related mortality. While cytotoxic chemotherapy remains the primary treatment for advanced GC, response rates are limited. Recent progresses, focused on molecular signalling within gastric cancer, have ignited new hope for potential therapeutic targets that may improve survival and/or reduce the toxic effects of traditional therapies. Carcinomas are generally initiated when critical regulatory genes get mutated, but the progression to malignancy is usually supported by the non-neoplastic cells that create a conducive environment for transformation and progression to occur. Interleukin 33 (IL-33) functions as a dual activity cytokine as it is also a nuclear factor. IL-33 is usually present in the nuclei of the cells. Upon tissue damage, it is released into the extracellular space and binds to its receptor, suppression of tumorigenicity 2 (ST2) L, which is expressed on the membranes of the target cells. IL-33 signalling activates the T Helper 2 (Th2) immune response among other responses. Although the studies on the role of IL-33 in gastric cancer are still in the early stages, they have revealed potentially important (though sometimes conflicting) functions or roles in cancer development and progression. The pro-tumorigenic roles include induction and the recruitment of tumor-associated immune cells, promoting metaplasia progression, and inducing stem cell like and EMT properties in gastric cancer cells. Therapeutic interventions to disrupt these functions may provide a unique strategy for gastric cancer prevention and treatment. This review aims to provide a summary of the role of IL-33 in GC, state its multiple functions in relation to GC, and show potential avenues for promising therapeutic investigation.
引用
收藏
页码:675 / 687
页数:13
相关论文
共 50 条
  • [1] Serum Interleukin-33 Levels in Patients with Gastric Cancer
    Pinghu Sun
    Qiwen Ben
    Shuiping Tu
    Wenjie Dong
    Xiaoguang Qi
    Yunlin Wu
    [J]. Digestive Diseases and Sciences, 2011, 56 : 3596 - 3601
  • [2] Serum Interleukin-33 Levels in Patients with Gastric Cancer
    Sun, Pinghu
    Ben, Qiwen
    Tu, Shuiping
    Dong, Wenjie
    Qi, Xiaoguang
    Wu, Yunlin
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2011, 56 (12) : 3596 - 3601
  • [3] Interleukin-33 System as Potential Biomarker and Therapeutic Target in Kawasaki Disease
    Okada, Seigo
    Yasudo, Hiroki
    Ohnishi, Yuji
    Matsuguma, Chie
    Fukano, Reiji
    Waniishi, Takako
    Hasegawa, Shunji
    [J]. CIRCULATION, 2022, 146
  • [4] Interleukin-33 biology with potential insights into human diseases
    Palmer, Gaby
    Gabay, Cem
    [J]. NATURE REVIEWS RHEUMATOLOGY, 2011, 7 (06) : 321 - 329
  • [5] Interleukin-33 biology with potential insights into human diseases
    Gaby Palmer
    Cem Gabay
    [J]. Nature Reviews Rheumatology, 2011, 7 : 321 - 329
  • [6] Interleukin-33 Expression does not Correlate with Survival of Gastric Cancer Patients
    Hu, Wenwei
    Li, Xiaodong
    Li, Qing
    Tan, Yan
    Xu, Bin
    Xie, Quanqin
    Deng, Xu
    Lu, Binfeng
    Jiang, Jingting
    Wu, Changping
    [J]. PATHOLOGY & ONCOLOGY RESEARCH, 2017, 23 (03) : 615 - 619
  • [7] Interleukin-33: A putative therapeutic target of neoangiogenesis associated with asthma
    Glineur, C.
    Duez, C.
    Tsicopoulos, A.
    [J]. REVUE FRANCAISE D ALLERGOLOGIE, 2015, 55 (05): : 372 - 378
  • [8] Interleukin-33/ST2 Axis as Potential Biomarker and Therapeutic Target in Kawasaki Disease
    Okada, Seigo
    Yasudo, Hiroki
    Ohnishi, Yuji
    Matsuguma, Chie
    Fukano, Reiji
    Motonaga, Takahiro
    Waniishi, Takako
    Hasegawa, Shunji
    [J]. INFLAMMATION, 2023, 46 (01) : 480 - 490
  • [9] Interleukin-33/ST2 Axis as Potential Biomarker and Therapeutic Target in Kawasaki Disease
    Seigo Okada
    Hiroki Yasudo
    Yuji Ohnishi
    Chie Matsuguma
    Reiji Fukano
    Takahiro Motonaga
    Takako Waniishi
    Shunji Hasegawa
    [J]. Inflammation, 2023, 46 : 480 - 490