Fungal quorum-sensing molecules and antiseptics: A promising strategy for biofilm modulation?

被引:3
|
作者
Marcomini, Emilli Karine [1 ]
Negri, Melyssa [1 ]
机构
[1] Univ Estadual Maringa, Maringa, Parana, Brazil
关键词
anti-infective agents; antifungal agents; bio fi lms; cell communication; fungal; quorum sensing; CANDIDA-ALBICANS; DRUG DISCOVERY; FARNESOL; GROWTH; MORPHOGENESIS; FLUCONAZOLE; TYROSOL; CHLORHEXIDINE; FILAMENTATION; COMBINATION;
D O I
10.1016/j.drudis.2023.103624
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
New strategies to control fungal biofilms are essential, especially those that interfere in the biofilm organization process and cellular communication, known as quorum sensing. The effect of antiseptics and quorum-sensing molecules (QSMs) have been considered with regard to this; however, little has been elucidated, particularly because studies are often restricted to the action of antiseptics and QSMs against a few fungal genera. In this review, we discuss progress reported in the literature thus far and analyze, through in silico methods, 13 fungal QSMs with regard to their physicochemical, pharmacological, and toxicity properties, including their mutagenicity, tumorigenicity, hepatotoxicity, and nephrotoxicity. From these in silico analyses, we highlight 4-hydroxyphenylacetic acid and tryptophol as having satisfactory properties and, thus, propose that these should be investigated further as antifungal agents. We also recommend future in vitro approaches to determine the association of QSMs with commonly used antiseptics as potential antibiofilm agents.
引用
收藏
页数:15
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