Unusual seven-membered ring sugars and nucleosides: synthesis and biological properties

被引：0

作者：

Manta, Stella ^{[1
,2
]}

Kollatos, Nikolaos ^{[1
]}

机构：

[1] Univ Thessaly, Dept Biochem & Biotechnol, Lab Bioorgan Chem, Larisa, Greece

[2] Univ thessaly, Dept Biochem & Biotechnol, Lab Bioorgan Chem, Viopolis 41500, Greece

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2023年 / 42卷 / 05期

关键词：

Septanoses; oxepane nucleosides; synthesis; biological evaluation; OLIGONUCLEOTIDES BEARING; IMINO SUGARS; POTENT; DESIGN; INHIBITORS; ANALOGS; SEPTANOSIDES; ISOFAGOMINE; IMINOSUGARS; EXPANSION;

D O I：

10.1080/15257770.2022.2151623

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Methods of the synthesis and the investigation of the properties of unnatural seven-memebered cyclic sugars and nucleosides, are of high interest. Septanoses provide conformationally more flexible sugars and due to their similarity to natural carbohydrates they have interesting and potentially useful physical, chemical, and biological properties. Additionally, nucleosides with seven-membered sugar moiety are commonly found in natural products and biologically active molecules. Modification of such nucleosides hold great promise as therapeutic agents. The present review describes the chemical synthesis and biological properties of septanoses as well as nucleosides containing septanosyl moieties.

引用

页码：407 / 425

页数：19

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