The present work was carried out during the COVID-19 pandemic, the objective was to analyze the differences in the practice of physical activity and self-regulation, in Raramuri families, before and during the contingency. The study was quantitative, descriptive, using a Likert-type questionnaire, validated by the Delphi method; to be applied in person to parents of 30 Raramuri families living in the Sierra Tarahumara of Chihuahua, Mexico, with security measures, as well as the support of interpreters. An analysis of variance of repeated measures before and after the pandemic by items and an ANOVA were performed. The results indi-cated that the daily practice of physical activity in boys and girls is 1.09 hours; from daily activities 0.75 to 1.4 hours, watching televi-sion, cell phone and recreation. In the Analysis of Variance of Repeated Measures of 2 (time) x 11 (items) in relation to before (M = 2.49, SD = 0.66) and during (M = 2.83, SD = 0.59) the pandemic, significant differences were observed, more frequently during the contingency, in five self-regulation activities related to: stop, think and then act; memorization; concentration and attention; sing with repetition and add words; and respect turns; as well as the time dedicated to physical activity. As conclusion, it is important to establish strategies that promote "positive" activities during and after the pandemic, based on the study that physical activity, play and interaction contribute to the well-being and development of the child.