Complexity-Building Photoinduced Cascade Involving Csp2-Csp3 Coupling of Aromatic Amides via [2+2] Reactivity of ESIPT- Generated o-Azaxylylenes

被引：3

作者：

Reddy, D. Sai ^{[1
]}

Novitskiy, Ivan M. ^{[1
]}

Kutateladze, Andrei G. ^{[1
]}

机构：

[1] Univ Denver, Dept Chem & Biochem, Denver, CO 80208 USA

来源：

ORGANIC LETTERS | 2023年

关键词：

PHOTOASSISTED SYNTHESIS;

D O I：

10.1021/acs.orglett.3c00092

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new mode for complexity-building photochemical cascades which offers experimentally simple transition metal-free intramolecular Csp2-Csp3 cross coupling of aromatic amides is attained via an unprecedented [2 + 2] reactivity of ESIPT-generated azaxylylenes. Coupled with short and straightforward postphoto-chemical modifications of the primary photoproducts, these cascades allow for a significant step-normalized growth of molecular complexity while accessing diverse and complex polyheterocyclic molecular architectures.

引用

页码：1131 / 1135

页数：5