Objective: Our aim in this study was to better understand the intervention effect of Pender's model on the physical and mental health of patients with diabetes mellitus.Methods: According to the principle of Preferred Reporting Items for Systematic Reviews and Meta -Analyses guidelines, various databases, including CNKI, Wanfang Data, SinoMed, VIP, Web of Science, Cochrane, PubMed and ScienceDirect, were searched to collect and select relevant reports for the implementation of a meta-analysis.Results: Ten randomized controlled trials in 6 foreign reports and 4 Chinese reports were included in this study. A total of 863 participants were involved, including 439 in the experimental group and 424 in the control group. Results of the meta-analysis show that Pender's model has a good intervention effect on the health knowledge (Z=3.371, p<0.050), self-management behaviour (Z=3.781, p<0.050) and psy-chological function (Z=2.902, p<0.050) of patients with diabetes mellitus as compared to the control group. The subgroup analysis showed that the intervention effect on self-management behaviour would not be affected by the measurement tool used (Z=3.295, p=0.001).Conclusions: Pender's model showed a good intervention effect on the health knowledge, self -management behaviour and psychological function of patients with diabetes mellitus.(c) 2022 Canadian Diabetes Association.