Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury

被引：56
|
作者：
Li, Qing-Sheng [1 ,2 ]
Jia, Yan-Jie [1 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou, Henan, Peoples R China
[2] Zhengzhou Univ, Acad Med Sci, Zhengzhou, Henan, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2023年 / 18卷 / 03期
基金：
中国国家自然科学基金;
关键词：
ferroptosis; immune response; inflammation; iron homeostasis; lipid metabolism; medicine; programmed cell death; spinal cord injury; traumatic brain injury; IRON ACCUMULATION; PEROXIDATION; LIPROXSTATIN-1; POLARIZATION; SUPPRESSION; SENSITIVITY; INHIBITION; MECHANISM; RECEPTOR; PROTECTS;
D O I：
10.4103/1673-5374.350187
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ferroptosis, a new non-necrotizing programmed cell death (PCD), is driven by iron-dependent phospholipid peroxidation. Ferroptosis plays a key role in secondary traumatic brain injury and secondary spinal cord injury and is closely related to inflammation, immunity, and chronic injuries. The inhibitors against ferroptosis effectively improve iron homeostasis, lipid metabolism, redox stabilization, neuronal remodeling, and functional recovery after trauma. In this review, we elaborate on the latest molecular mechanisms of ferroptosis, emphasize its role in secondary central nervous trauma, and update the medicines used to suppress ferroptosis following injuries.
引用
收藏
页码：506 / 512
页数：7
相关论文
共 50 条
  • [1] Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury
    Qing-Sheng Li
    Yan-Jie Jia
    Neural Regeneration Research, 2023, 18 (03) : 506 - 512
  • [2] Ferroptosis is a new therapeutic target for spinal cord injury
    Bai, Xin-Yue
    Liu, Xiao-Long
    Deng, Zhi-Zhong
    Wei, Dong-Min
    Zhang, Die
    Xi, Hui-Lin
    Wang, Qing-Yan
    He, Meng-Ze
    Yang, Yan-Ling
    FRONTIERS IN NEUROSCIENCE, 2023, 17
  • [3] Potential immunotherapies for traumatic brain and spinal cord injury
    Raj Putatunda
    John R.Bethea
    Wen-Hui Hu
    中华创伤杂志英文版, 2018, 21 (03) : 125 - 136
  • [4] Potential immunotherapies for traumatic brain and spinal cord injury
    Putatunda, Raj
    Bethea, John R.
    Hu, Wen-Hui
    CHINESE JOURNAL OF TRAUMATOLOGY, 2018, 21 (03) : 125 - 136
  • [5] Traumatic brain and spinal cord injury
    Dias, MS
    PEDIATRIC CLINICS OF NORTH AMERICA, 2004, 51 (02) : 271 - +
  • [6] mTOR pathway: A potential therapeutic target for spinal cord injury
    Ding, Yi
    Chen, Qin
    BIOMEDICINE & PHARMACOTHERAPY, 2022, 145
  • [7] Matrix metalloproteinases: Potential therapeutic target in spinal cord injury
    Duchossoy, Y
    Arnaud, S
    Feldblum, S
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2001, 39 (04) : 362 - 367
  • [8] Traumatic axonal injury in the spinal cord evoked by traumatic brain injury
    Czeiter, Endre
    Pal, Jozsef
    Kovesdi, Erzsebet
    Bukovics, Peter
    Luckl, Janos
    Doczi, Tamas
    Buki, Andras
    JOURNAL OF NEUROTRAUMA, 2008, 25 (03) : 205 - 213
  • [9] Traumatic brain injury in US Veterans with traumatic spinal cord injury
    Creasey, Graham H.
    Lateva, Zoia C.
    Rose, Sophia Miryam Schuessler-Fiorenza
    Rose, Jon
    JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT, 2015, 52 (06): : 669 - 676
  • [10] Ferroptosis: A Novel Therapeutic Direction of Spinal Cord Injury
    Zhao, Qianlong
    Liu, Feifei
    Zhou, Bangyu
    Liu, Hongzhi
    Wang, Xiaowei
    Li, Shaobo
    COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2022, 2022
12345