Traumatic brain injury and post-traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers

被引：24

作者：

Weiner, Michael W. ^{[1
,2
,3
,4
,5
]}

Harvey, Danielle ^{[6
]}

Landau, Susan M. ^{[7
]}

Veitch, Dallas P. ^{[1
,8
]}

Neylan, Thomas C. ^{[4
,5
]}

Grafman, Jordan H. ^{[9
]}

Aisen, Paul S. ^{[10
]}

Petersen, Ronald C. ^{[11
]}

Jack, Clifford R., Jr. ^{[12
]}

Tosun, Duygu ^{[1
,2
]}

Shaw, Leslie M. ^{[13
]}

Trojanowski, John Q. ^{[13
]}

Saykin, Andrew J. ^{[14
,15
,16
]}

Hayes, Jacqueline ^{[1
,8
]}

De Carli, Charles ^{[17
,18
]}

机构：

[1] Ctr Imaging Neurodegenerat Dis, Dept Vet Affairs Med Ctr, San Francisco, CA USA

[2] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[6] Univ Calif Davis, Div Biostat, Dept Publ Hlth Sci, Davis, CA 95616 USA

[7] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[8] Northern Calif Inst Res & Educ NCIRE, Dept Vet Affairs Med Ctr, San Francisco, CA USA

[9] Northwestern Univ, Sch Med, Shirley Ryan Abil Lab, Chicago, IL 60611 USA

[10] Univ Southern Calif, Alzheimers Therapeut Res Inst, La Jolla, CA USA

[11] Mayo Clin, Dept Neurol, Rochester, MN USA

[12] Mayo Clin, Dept Radiol, Rochester, MN USA

[13] Univ Penn, Sch Med, Ctr Neurodegenerat Res, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[14] Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA

[15] Indiana Univ Sch Med, Alzheimers Dis Res Ctr, Indianapolis, IN 46202 USA

[16] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA

[17] Univ Calif Davis, Dept Neurol, Davis, CA 95616 USA

[18] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 03期

关键词：

Alzheimer's disease; amyloid; cerebrovascular disease; cognitive decline; head injury; neurodegeneration; post-traumatic stress disorder; tau; traumatic brain injury; veterans; OLDER-ADULTS; COGNITIVE DECLINE; DEMENTIA; RISK; VETERANS; DEPRESSION; ACCURACY; HISTORY; PTSD;

D O I：

10.1002/alz.12712

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Epidemiological studies report an association between traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) and clinically diagnosed Alzheimer's disease (AD). We examined the association between TBI/PTSD and biomarker-defined AD. Methods We identified 289 non-demented veterans with TBI and/or PTSD and controls who underwent clinical evaluation, cerebrospinal fluid (CSF) collection, magnetic resonance imaging (MRI), amyloid beta (A beta) and tau positron emission tomography, and apolipoprotein E testing. Participants were followed for up to 5.2 years. Results Exposure groups (TBI, PTSD, and TBI + PTSD) had higher prevalence of mild cognitive impairment (MCI: P < .0001) and worse Mini-Mental State Examination scores (PTSD: P = .008; TBI & PTSD: P = .009) than controls. There were no significant differences in other cognitive scores, MRI volumes, A beta or tau accumulation, or in most longitudinal measures. Discussion TBI and/or PTSD were not associated with elevated AD biomarkers. The poorer cognitive status of exposed veterans may be due to other comorbid pathologies.

引用

页码：884 / 895

页数：12

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