Therapeutic Phages as Modulators of the Immune Response: Practical Implications

While the medical community awaits formal proof of the efficacy of phage therapy, as is required by evidence-based medicine, existing data suggest that phages could also be applied based on their non-antibacterial action, especially phage-mediated immunomodulation. Promising avenues have been revealed by findings indicating that phages may mediate diverse actions in the immune system, while the list of phages able to dampen the aberrant immunity associated with a variety of disorders continuously grows. Here we summarize what is known in this field and possible options for the future. While available data are still scarce and preliminary, it appears that "phage repurposing" is worthy of more research, which could reveal new perspectives on applying phage therapy in contemporary medicine. Recent data strongly suggest that phages may elicit immunomodulating effects. Those effects may be phage specific and cause downregulation of inflammatory and autoimmune reactions. Those data significantly expand current knowledge on biology of phages opening new avenues for "phage repurposing".