Steroidal alkaloids from the roots of Veratrum stenophyllum

被引：0

作者：

Zhou, Zhong-Shun ^{[1
]}

Liu, Yang -Yang ^{[1
]}

Zhu, Yan-Yan ^{[1
]}

Hu, Bin-Yuan ^{[1
]}

He, Ying-Jie ^{[1
]}

Luo, Xiao- Dong ^{[1
,2
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ & Yunnan Prov, Yunnan Characterist Plant Extract Lab,Key Lab Med, Kunming 650500, Peoples R China

[2] Chinese Acad Sci Kunming, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources We, Kunming 650201, Peoples R China

来源：

FITOTERAPIA | 2023年 / 166卷

关键词：

Steroidal alkaloids; Veratrum stenophyllum; Cytotoxic bioactivity; ANTITUMOR-ACTIVITY; RHIZOMES; DNA;

D O I：

10.1016/j.fitote.2023.105464

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new steroidal alkaloids, veratrasines A -C (1-3), along with ten known analogues (4-13) were isolated from the roots of Veratrum stenophyllum. Their structures were elucidated by NMR and HRESIMS data and comparison with the reported data in the literatures. A plausible biosynthetic pathway for 1 and 2 were pro-posed. Compounds 1, 3, and 8 showed moderate cytotoxic activity against MHCC97H and H1299 cell lines.

引用

页数：6

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