Administration of amyloid-β oligomer to the buccal ganglia may reduce food intake and cholinergic synaptic responses within the feeding neural circuit in Aplysia kurodai

被引：0

作者：

Nagahama, Tatsumi ^{[1
,2
]}

Nakajima, Hiroshi ^{[1
]}

Wakuta, Mizuki ^{[1
]}

Kasahara, Yuse ^{[1
]}

Narita, Kouki ^{[1
]}

Nagahama, Setsuko ^{[2
]}

机构：

[1] Toho Univ, Fac Pharmaceut Sci, Dept Biophys, Funabashi 2748510, Japan

[2] Teikyo Heisei Univ, Fac Hlth & Med Sci, Tokyo 1708445, Japan

来源：

NEUROSCIENCE RESEARCH | 2023年 / 196卷

关键词：

Amyloid; Oligomer; Anorexia; Buccal ganglia; Surgical treatment; Cholinergic synapse; Dysfunction; Cholinergic hypothesis; INDUCED NEURONAL DYSFUNCTION; GENERATING FIRING PATTERNS; ALZHEIMERS-DISEASE; ACETYLCHOLINE-RECEPTORS; JAW MOTONEURONS; BRAIN-STEM; MEMORY; GLUTAMATE; MECHANISM; PEPTIDE;

D O I：

10.1016/j.neures.2023.06.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Anorexia is a behavioral change caused by functional brain disorders in patients with Alzheimer's disease (AD). Amyloid-beta (1-42) oligomers (o-A beta) are possible causative agents of AD that impair signaling via synaptic dysfunction. In this study, we used Aplysia kurodai to study functional disorders of the brain through o-A beta. Administration of o-A beta to the buccal ganglia (feeding brain for oral movements) by surgical treatment signifi-cantly reduced food intake for at least five days. Furthermore, we explored the effects of o-A beta on the synaptic function in the feeding neural circuit, focusing on a specific inhibitory synaptic response in jaw-closing motor neurons produced by cholinergic buccal multi-action neurons because we recently found that this cholinergic response decreases with aging, which is consistent with the cholinergic hypothesis for aging. Administration of o-A beta to the buccal ganglia significantly reduced the synaptic response within minutes, whereas administration of amyloid-beta (1-42) monomers did not. These results suggest that o-A beta may impair the cholinergic synapses, even in Aplysia, which is consistent with the cholinergic hypothesis for AD.

引用

页码：32 / 39

页数：8