Synthesis of Axially Chiral Biaryls through Cobalt(II)-Catalyzed Atroposelective C-H Arylation

被引：19

作者：

Wu, Yong-Jie ^{[1
]}

Wang, Zhen-Kai ^{[1
]}

Jia, Zhen-Sheng ^{[1
]}

Chen, Jia-Hao ^{[1
]}

Huang, Fan-Rui ^{[1
]}

Zhan, Bei-Bei ^{[1
]}

Yao, Qi-Jun ^{[1
]}

Shi, Bing-Feng ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Ctr Chem Frontier Technol, Dept Chem, Hangzhou 310027, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2023年 / 62卷 / 40期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Arylation; Atroposelectivity; C-H Activation; Cobalt; Dynamic Kinetic Asymmetric Transformations; ASYMMETRIC-SYNTHESIS; ARYLBORONIC ACIDS; ATROPISOMERS; CONSTRUCTION; OLEFINATION; ACTIVATION; INDOLE; FUNCTIONALIZATION; ALKYLATION; CATALYST;

D O I：

10.1002/anie.202310004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly efficient synthesis of axially chiral biaryl amines through cobalt-catalyzed atroposelective C-H arylation using easily accessible cobalt(II) salt and salicyloxazoline ligand has been reported. This methodology provides a straightforward and sustainable access to a broad range of enantioenriched biaryl-2-amines in good yields (up to 99%) with excellent enantioselectivities (up to 99% ee). The synthetic utility of the unprecedented method is highlighted by its scalability and diverse transformations.

引用

页数：6

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