Vaccines to Treat Substance Use Disorders: Current Status and Future Directions

被引:1
|
作者
Lu, Tangsheng [1 ,2 ,3 ]
Li, Xue [1 ,2 ,3 ]
Zheng, Wei [4 ,5 ]
Kuang, Chenyan [6 ]
Wu, Bingyi [7 ]
Liu, Xiaoxing [8 ]
Xue, Yanxue [1 ,2 ]
Shi, Jie [1 ,2 ]
Lu, Lin [1 ,2 ,4 ,5 ,8 ]
Han, Ying [1 ,2 ]
机构
[1] Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
[2] Peking Univ, Beijing Key Lab Drug Dependence Res, Beijing 100191, Peoples R China
[3] Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China
[4] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
[5] Peking Univ, McGovern Inst Brain Res, PKU IDG, Beijing 100871, Peoples R China
[6] Hebei Med Univ, Coll Forens Med, Collaborat Innovat Ctr Forens Med Mol Identificat, Hebei Key Lab Forens Med, Shijiazhuang 050017, Peoples R China
[7] Xinxiang Med Univ, Affiliated Hosp 1, Henan Key Lab Neurorestoratol, Xinxiang 453100, Peoples R China
[8] Peking Univ, Peking Univ Sixth Hosp, Inst Mental Hlth, NHC Key Lab Mental Hlth,Natl Clin Res Ctr Mental D, Beijing 100191, Peoples R China
关键词
vaccine; substance use disorders; addiction; immunotherapy; antibody; GENERATION NICOTINE VACCINE; MORPHINE CONJUGATE VACCINE; COCAINE VACCINE; SMOKING-CESSATION; EFFICACY; HEROIN; FENTANYL; ANTINOCICEPTION; NANOVACCINE; DEPENDENCE;
D O I
10.3390/pharmaceutics16010084
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Addiction, particularly in relation to psychostimulants and opioids, persists as a global health crisis with profound social and economic ramifications. Traditional interventions, including medications and behavioral therapies, often encounter limited success due to the chronic and relapsing nature of addictive disorders. Consequently, there is significant interest in the development of innovative therapeutics to counteract the effects of abused substances. In recent years, vaccines have emerged as a novel and promising strategy to tackle addiction. Anti-drug vaccines are designed to stimulate the immune system to produce antibodies that bind to addictive compounds, such as nicotine, cocaine, morphine, methamphetamine, and heroin. These antibodies effectively neutralize the target molecules, preventing them from reaching the brain and eliciting their rewarding effects. By obstructing the rewarding sensations associated with substance use, vaccines aim to reduce cravings and the motivation to engage in drug use. Although anti-drug vaccines hold significant potential, challenges remain in their development and implementation. The reversibility of vaccination and the potential for combining vaccines with other addiction treatments offer promise for improving addiction outcomes. This review provides an overview of anti-drug vaccines, their mechanisms of action, and their potential impact on treatment for substance use disorders. Furthermore, this review summarizes recent advancements in vaccine development for each specific drug, offering insights for the development of more effective and personalized treatments capable of addressing the distinct challenges posed by various abused substances.
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页数:17
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