CD96 as a Potential Immune Regulator in Cancers

被引：13

作者：

Feng, Shikai ^{[1
]}

Isayev, Orkhan ^{[2
]}

Werner, Jens ^{[1
,3
,4
]}

Bazhin, Alexandr V. ^{[1
,3
,4
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Dept Gen Visceral & Transplant Surg, D-81377 Munich, Germany

[2] Azerbaijan Med Univ, Dept Cytol Embryol & Histol, AZ-1022 Baku, Azerbaijan

[3] German Canc Consortium DKTK, Partner Site Munich, D-81377 Munich, Germany

[4] Bavarian Canc Res Ctr BZKF, D-91054 Erlangen, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 02期

关键词：

CD96; CD155; CD226; immune checkpoint molecules; immune modulation; TIGIT; CELL-ADHESION; MOLECULAR-CLONING; RECEPTOR; TIGIT; POLIOVIRUS; CD226; ACTIVATION; EXPRESSION; INTERFACE; TACTILE;

D O I：

10.3390/ijms24021303

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of CTLA-4 and PD-1 checkpoints has prompted scientific researchers and the pharmaceutical industry to develop and conduct extensive research on tumor-specific inhibitors. As a result, the list of potential immune checkpoint molecules is growing over time. Receptors for nectin and nectin-like proteins have recently emerged as promising targets for cancer immunotherapy. Potential immune checkpoints, including CD226, TIGIT, and CD96, belong to this receptor class. Among them, CD96 has received little attention. In this mini-review, we aim to discuss the basic biology of CD96 as well as the most recent relevant research on this as a promising candidate for cancer immunotherapy.

引用

页数：12

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