Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment

被引：15
|
作者：
Butterfield, D. Allan [1 ]
机构：
[1] Univ Kentucky, Sanders Brown Ctr Aging, Dept Chem, Lexington, KY 40506 USA
来源：
ANTIOXIDANTS | 2023年 / 12卷 / 02期
关键词：
lipid peroxidation; Abeta and oxidative stress; neuronal loss; key metabolic pathways involved in MCI; potential therapeutic strategies for MCI; AMYLOID BETA-PEPTIDE; ALZHEIMERS-DISEASE BRAIN; TRANSGENIC MOUSE MODEL; KNOCK-IN MICE; LIPID-PEROXIDATION PRODUCT; ALPHA-LIPOIC ACID; PROTEOMIC IDENTIFICATION; A-BETA; NEURODEGENERATIVE DISEASES; NUTRACEUTICAL FORMULATION;
D O I：
10.3390/antiox12020462
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Amnestic mild cognitive impairment (MCI), arguably the earliest clinical stage of Alzheimer disease (AD), is characterized by normal activities of daily living but with memory issues but no dementia. Oxidative stress, with consequent damaged key proteins and lipids, are prominent even in this early state of AD. This review article outlines oxidative stress in MCI and how this can account for neuronal loss and potential therapeutic strategies to slow progression to AD.
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页数：16
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