Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system

被引：2

作者：

Li, Kai ^{[1
]}

Feng, Zhanpeng ^{[1
]}

Xiong, Zhiwei ^{[1
]}

Pan, Jun ^{[1
]}

Zhou, Mingfeng ^{[1
]}

Li, Weizhao ^{[1
]}

Ou, Yichao ^{[1
]}

Wu, Guangsen ^{[1
]}

Che, Mengjie ^{[1
]}

Gong, Haodong ^{[1
]}

Peng, Junjie ^{[1
]}

Wang, Xingqin ^{[1
]}

Qi, Songtao ^{[1
]}

Peng, Junxiang ^{[1
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Inst Brain Dis, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2024年 / 19卷 / 10期

基金：

中国国家自然科学基金;

关键词：

arginine vasopressin; growth hormone; hypothalamo-neurohypophyseal system; hypothalamus; injury; insulin-like growth factor 1; oxytocin; regeneration; RECOVERY; NERVE; REGENERATION; TRANSECTION; OXYTOCIN; NEURONS; IGF-1;

D O I：

10.4103/1673-5374.389358

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, we established a specific hypothalamic axon injury model by inducing hypothalamic pituitary stalk electric lesions in male mice. We then treated mice by intraperitoneal administration of growth hormone. Our results showed that growth hormone increased the expression of insulin-like growth factor 1 and its receptors, and promoted the survival of hypothalamic neurons, axonal regeneration, and vascular reconstruction from the median eminence through the posterior pituitary. Altogether, this alleviated hypothalamic injury-caused central diabetes insipidus and anxiety. These results suggest that growth hormone can promote axonal reconstruction after hypothalamic injury by regulating the growth hormone-insulin-like growth factor 1 axis.

引用

页码：2249 / 2258

页数：10

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[1] Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system
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Zhanpeng Feng
Zhiwei Xiong
Jun Pan
Mingfeng Zhou
Weizhao Li
Yichao Ou
Guangsen Wu
Mengjie Che
Haodong Gong
Junjie Peng
Xingqin Wang
Songtao Qi
Junxiang Peng
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