Anti-PL-7, anti-Ro/SSA, anti-Mi-2, and anti-TIF1-γ correlate with specific patterns of histopathologic features in dermatomyositis: An analysis of 39 skin biopsy specimens from 25 patients

被引：0

作者：

Bennett, Raven ^{[1
]}

Bradley, Katherine ^{[1
]}

Stevanovic, Mirjana ^{[1
]}

McFadden, Jason R. ^{[2
]}

Chaudhari, Advaita S. ^{[3
]}

Ramos-Rodriguez, Alvaro J. ^{[4
]}

Yan, Shaofeng ^{[1
,4
]}

Momtahen, Shabnam ^{[1
,4
]}

LeBlanc, Robert E. ^{[1
,4
]}

Cloutier, Jeffrey M. ^{[1
,4
]}

Salem, Iman ^{[5
]}

Grand, David G. ^{[5
]}

Hodson, Emma L. ^{[5
]}

Sriharan, Aravindhan ^{[1
,4
,6
]}

机构：

[1] Dartmouth Geisel Sch Med, 1 Rope Ferry Rd, Hanover, NH 03755 USA

[2] NHGRI, NIH, Undiagnosed Dis Program, Rockville, MD USA

[3] Dartmouth Coll, Hanover, NH USA

[4] Dartmouth Hitchcock Med Ctr, Dept Pathol & Lab Med, Lebanon, NH USA

[5] Dartmouth Hitchcock Med Ctr, Dept Dermatol, Lebanon, NH USA

[6] Dartmouth Geisel Sch Med, Dartmouth Hitchcock Med Ctr, Dept Pathol & Lab Med, Lebanon, NH 03766 USA

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 2024年 / 51卷 / 04期

关键词：

anti-Mi-2; anti-PL-7; anti-Ro/SSA; anti-TIF1-gamma; dermatomyositis; myositis-associated antibodies (MAAs); myositis-specific antibodies (MSAs); serology; LUPUS-ERYTHEMATOSUS; CLINICAL PHENOTYPE; MYOSITIS; AUTOANTIBODIES; POLYMYOSITIS; EOSINOPHILS; RISK;

D O I：

10.1111/cup.14578

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: In dermatomyositis (DM), myositis-specific and myositis-associated antibodies have been correlated with clinical features. It is unknown if histopathologic findings in lesional skin biopsies correlate with serologic subtypes of DM. Methods: A retrospective chart review of patients with DM was performed. Patients with myositis antibodies and DM lesional skin biopsies were included in the study. Skin biopsies were reviewed by blinded dermatopathologists for 20 histopathologic features. Results: There was a statistically significant (p < 0.05) association between anti-PL-7 serology and decreased degree of vacuolar degeneration, necrotic keratinocytes, and thickening of the epidermal basement membrane. Anti-aminoacyl tRNA synthetase (anti-ARS) antibodies had the same significant negative association with degree of vacuolar degeneration, necrotic keratinocytes, and thickening of the epidermal basement membrane. A similar pattern was seen with an anti-cytoplasmic serology; where there was a significant association with an increased degree of vacuolar degeneration and necrotic keratinocytes, and a nonsignificant trend of minimally thickened epidermal basement membrane. There was a statistically significant association between anti-Ro/SSA serology and increased degree of vacuolar degeneration. Anti-TIF1-gamma serology was significantly associated with the increased presence of necrotic keratinocytes and pigment incontinence, and displayed a pattern of increased neutrophils. There was a significant association between anti-Mi-2 antibodies and pigment incontinence, as well as between myositis-specific antibodies and pigment incontinence. A statistically significant positive association was found between nuclear antibodies and degree of vacuolar degeneration, thickened epidermal basement membrane, pigment incontinence, and epidermal atrophy. Conclusion: In patients with DM, some specific serotypes, including anti-PL-7, anti-Ro/SSA, anti-Mi-2, and anti-TIF1-gamma, may have characteristic histopathologic features.

引用

页码：317 / 326

页数：10

共 1 条

[1] Clinical features of anti-TIF1-α antibody-positive dermatomyositis patients are closely associated with coexistent dermatomyositis-specific autoantibodies and anti-TIF1-γ or anti-Mi-2 autoantibodies
Muro, Yoshinao
Ishikawa, Asuka
Sugiura, Kazumitsu
Akiyama, Masashi
RHEUMATOLOGY, 2012, 51 (08) : 1508 - 1513

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