Biocidal Activity of Chitosan Aspartate Nanoparticles

被引:1
|
作者
Shipovskaya, A. B. [1 ]
Lugovitskaya, T. N. [2 ]
Zudina, I. V. [1 ]
机构
[1] Saratov NG Chernyshevskii State Univ, Saratov 410012, Russia
[2] Ural Fed Univ, Ekaterinburg 620002, Russia
基金
俄罗斯科学基金会;
关键词
chitosan aspartate; nanoparticles; Escherichia coli; Staphylococcus aureus; fibroblasts; keratinocytes; epithelial cells; ANTIBACTERIAL ACTIVITY; DERIVATIVES; CHITIN; MODE;
D O I
10.1134/S0026261722602378
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
-The biological activity of chitosan aspartate particles formed in the chitosan-L-aspartic acid-water system at the initial stage of phase separation was investigated. Cultivation of Staphylococcus aureus 209 P and Escherichia coli 113-13 in the medium supplemented with our nanoparticles resulted in massive death of the bacterial cultures. The biocidal activity against gram-positive bacteria was most pronounced. Biological tests revealed high biocompatibility of our chitosan nanoparticles and their ability to accelerate the proliferative activity of the cultures of epidermal and epithelial cells. Our results indicate that our chitosan aspartate nanoparticles are promising for medico-biological and pharmaceutical applications.
引用
收藏
页码:75 / 82
页数:8
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