Intranasal Ion-Triggered In Situ Delivery System of Virus-like Particles: Development Using the Quality by Design Approach

被引：1

作者：

Bakhrushina, Elena O. ^{[1
]}

Mikhel, Iosif B. ^{[1
]}

Kondratieva, Valeriya M. ^{[2
]}

Zubareva, Irina M. ^{[1
]}

Kosenkova, Svetlana I. ^{[1
]}

Belyatskaya, Anastasiya V. ^{[1
]}

Stepanova, Olga I. ^{[1
]}

Krasnyuk Jr, Ivan I. ^{[1
]}

Grebennikova, Tatyana V. ^{[2
]}

Krasnyuk, Ivan I. ^{[1
]}

机构：

[1] Sechenov Univ, IM Sechenov Moscow State Med Univ 1, AP Nelyubin Inst Pharm, Moscow 119048, Russia

[2] Gamaleya Natl Ctr Epidemiol & Microbiol, Dept Epidemiol & Microbiol, Moscow 123098, Russia

来源：

POLYMERS | 2024年 / 16卷 / 05期

关键词：

in situ forming; VLP; intranasal delivery; vaccines; quality by design; ion-triggered polymers; gellan gum; VIVO EVALUATION; SUPPOSITORY; FORMULATION; GEL;

D O I：

10.3390/polym16050685

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The rapid growth in the prevalence of infectious diseases requires timely action from drug developers. In recent years, the COVID-19 pandemic has demonstrated the unpreparedness of the population for such emergencies. The introduction of modern methods of Design of Experiments (DoE) is required to accelerate the process of drug development and bring a drug to market. The main objective of this study was to develop an ion-triggered in situ system for intranasal delivery of VLP using a Quality by Design approach. Based on a literature review and initial studies, the key QTPP, CQA, CPP, and CMA were identified to develop a novel delivery system for virus-like particles. As a result of the studies on the quality attributes of the developed delivery system, an ion-triggered in situ gel meeting all the specified parameters was obtained using the Quality by Design method.

引用

页数：16

共 50 条

[1] Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine
Velasquez, Lissette S.
Shira, Samantha
Berta, Alice N.
Kilbourne, Jacquelyn
Medi, Babu M.
Tizard, Ian
Ni, Yawei
Arntzen, Charles J.
Herbst-Kralovetz, Melissa M.
VACCINE, 2011, 29 (32) : 5221 - 5231
[2] DEVELOPMENT OF ENDOSOMOLYTIC VIRUS-LIKE PARTICLES FORGENE DELIVERY
CHIOCCA, S
WAGNER, E
COTTEN, M
JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 224 - 224
[3] Protein delivery using engineered virus-like particles
Kaczmarczyk, Stanislaw J.
Sitaraman, Kalavathy
Young, Howard A.
Hughes, Stephen H.
Chatterjee, Deb K.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (41) : 16998 - 17003
[4] Virus-Like Particles as a Vaccine Delivery System: Myths and Facts
Roy, Polly
Noad, Rob
PHARMACEUTICAL BIOTECHNOLOGY, 2009, 655 : 145 - 158
[5] Virus-like particles as a vaccine delivery system - Myths and facts
Roy, Polly
Noad, Rob
HUMAN VACCINES, 2008, 4 (01): : 5 - 12
[6] Intracellular delivery of virus-like particles using a sheddable linker
Hagge, Laurel M.
Shahrivarkevishahi, Arezoo
Al-Kharji, Noora M.
Chen, Zhuo
Brohlin, Olivia R.
Trashi, Ikeda
Tumac, Alisia
C. Herbert, Fabian
Adlooru, Abhinay Varma
Lee, Hamilton
Firouzi, Hamid Reza
Cornelius, Samuel A.
De Nisco, Nicole J.
Gassensmith, Jeremiah J.
JOURNAL OF MATERIALS CHEMISTRY B, 2023, 11 (30) : 7126 - 7133
[7] Development of a microRNA delivery system based on bacteriophage MS2 virus-like particles
Pan, Yang
Zhang, Yuan
Jia, Tingting
Zhang, Kuo
Li, Jinming
Wang, Lunan
FEBS JOURNAL, 2012, 279 (07) : 1198 - 1208
[8] Establishment of Liver-Targeting Delivery System Using Hepatitis E Virus-Like Particles
Kim, Jung-Hee
Hur, Wonhee
Lee, Eun Byul
Choi, Jung Eun
Yoon, Seung Kew
HEPATOLOGY, 2014, 60 : 826A - 827A
[9] Generation of Antibodies Against Ion Channels Using Virus-Like Particles
Rucker, Joseph
Payne, Riley
Baxter, Sabine
Tucker, David
Willis, Sharon H.
Doranz, Benjamin J.
BIOPHYSICAL JOURNAL, 2011, 100 (03) : 91 - 91
[10] The intranasal delivery of non-specific virus-like particles elicits heightened and accelerated immune responses to influenza virus
Richert, Laura
Rynda-Apple, Agnieszka
Wiley, James
Douglas, Trevor
Harmsen, Allen
JOURNAL OF IMMUNOLOGY, 2012, 188

← 1 2 3 4 5 →