Ginseng Glucosyl Oleanolate from Ginsenoside Ro, Exhibited Anti-Liver Cancer Activities via MAPKs and Gut Microbiota In Vitro/Vivo

被引：5

作者：

Ai, Zhiyi ^{[1
,2
]}

Liu, Sitong ^{[1
,2
]}

Zhang, Junshun ^{[1
,2
]}

Hu, Yue ^{[1
,2
]}

Tang, Ping ^{[1
,2
]}

Cui, Linlin ^{[1
,2
]}

Wang, Xinzhu ^{[1
,2
]}

Zou, Hongyang ^{[1
,2
]}

Li, Xia ^{[1
,2
]}

Liu, Jingsheng ^{[1
,2
]}

Nan, Bo ^{[1
,2
]}

Wang, Yuhua ^{[1
,2
]}

机构：

[1] Jilin Agr Univ, Coll Food Sci & Engn, Changchun 130118, Peoples R China

[2] Jilin Agr Univ, Jilin Prov Innovat Ctr Food Biol Manufacture, Changchun 130118, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2024年 / 72卷 / 14期

关键词：

ginseng glucosyl oleanolate; HepG2; cells; cellproliferation; intestinal flora; SCFAs metabolism; CELL-CYCLE ARREST; HEPATOCELLULAR-CARCINOMA; SIGNALING PATHWAY; APOPTOSIS; EXPRESSION; INHIBITION; SAPONINS;

D O I：

10.1021/acs.jafc.3c08150

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Ginseng is widely recognized for its diverse health benefits and serves as a functional food ingredient with global popularity. Ginsenosides with a broad range of pharmacological effects are the most crucial active ingredients in ginseng. This study aimed to derive ginseng glucosyl oleanolate (GGO) from ginsenoside Ro through enzymatic conversion and evaluate its impact on liver cancer in vitro and in vivo. GGO exhibited concentration-dependent HepG2 cell death and markedly inhibited cell proliferation via the MAPK signaling pathway. It also attenuated tumor growth in immunocompromised mice undergoing heterograft transplantation. Furthermore, GGO intervention caused a modulation of gut microbiota composition by specific bacterial populations, including Lactobacillus, Bacteroides, Clostridium, Enterococcus, etc., and ameliorated SCFA metabolism and colonic inflammation. These findings offer promising evidence for the potential use of GGO as a natural functional food ingredient in the prevention and treatment of cancer.

引用

页码：7845 / 7860

页数：16

共 1 条

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FITOTERAPIA, 2022, 162

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