A Sub-mm3 Wireless Neural Stimulator IC for Visual Cortical Prosthesis With Optical Power Harvesting and 7.5-kb/s Data Telemetry

被引：3

作者：

Lee, Jungho ^{[1
]}

Letner, Joseph G. ^{[2
]}

Lim, Jongyup ^{[1
]}

Atzeni, Gabriele ^{[3
]}

Liao, Jiawei ^{[3
]}

Kamboj, Abhilasha ^{[4
]}

Mani, Bhavika ^{[4
]}

Jeong, Seokhyeon ^{[5
,6
]}

Kim, Yejoong ^{[5
,6
]}

Sun, Yi ^{[1
]}

Koo, Beomseo ^{[2
]}

Richie, Julianna ^{[2
]}

Valle, Elena della ^{[2
]}

Patel, Paras R. ^{[2
]}

Sylvester, Dennis ^{[1
]}

Kim, Hun-Seok ^{[1
]}

Jang, Taekwang ^{[3
]}

Phillips, Jamie D. ^{[4
]}

Chestek, Cynthia A. ^{[7
,8
]}

Weiland, James ^{[9
,10
]}

Blaauw, David ^{[1
]}

机构：

[1] Univ Michigan, Dept Elect & Comp Engn, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[3] Swiss Fed Inst Technol, Dept Informat Technol & Elect Engn, CH-8092 Zurich, Switzerland

[4] Univ Delaware, Dept Elect & Comp Engn, Newark, NJ 19716 USA

[5] Univ Michigan, Dept Elect & Comp Engn, Ann Arbor, MI 48109 USA

[6] Cubeworks Inc, Ann Arbor, MI 48109 USA

[7] Univ Michigan, Dept Biomed Engn, Dept Elect & Comp Engn, Ann Arbor, MI 48109 USA

[8] Univ Michigan, Dept Robot, Ann Arbor, MI 48109 USA

[9] Univ Michigan, Dept Biomed Engn, Dept Ophthalmol & Visual Sci, Ann Arbor, MI 48109 USA

[10] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA

来源：

IEEE JOURNAL OF SOLID-STATE CIRCUITS | 2024年 / 59卷 / 04期

基金：

美国国家科学基金会;

关键词：

Bio-implant mote; brain-machine interface (BMI); charge balance (CB); flip chip bonding; low-power optical receiver (ORX); Manchester encoding; switched-capacitor stimulation (SCS); transimpedance amplifier (TIA); visual cortical prosthesis (VCP); ACUITY; TISSUE;

D O I：

10.1109/JSSC.2023.3349179

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

This article proposes StiMote, an untethered, free-floating and individually addressable stimulator mote designed for visual cortex stimulation, aimed at vision restoration. The system is optically powered by a custom photovoltaic (PV) layer. In addition, the photodiode (PD) layer captures the light modulation and forwards it to the optical receiver (ORX) including a tranimpedance amplifier. Translated instructions can assign a unique slot, up to 1024 available, to each mote within the time-division multiple access (TDMA) framework. In this work, we propose an automatic charge balance (CB) technique that monitors the injected charge to balance in bi-phasic switched-capacitor stimulation (SCS). The chip was confirmed fully functional when operated completely wirelessly using harvested light. Measurement results revealed a power consumption of 4.48 mu W with a 7.5-kb/s optical downlink data rate, corresponding to continuous updates at 2.5 Hz of 1024 motes to their individual 3-b stimulation intensity levels. The dc-dc converter, responsible for providing high voltage for stimulation, demonstrated 4.3-V output voltage when unloaded, with a maximum efficiency of 67.4%. The proposed CB circuit exhibited linear controllability of stimulation charge up to 16 nC, with a charge imbalance of less than 0.2 nC. Furthermore, in vitro testing confirmed the absence of chemical reactions at electrodes, and in vivo experiments conducted on live rats verified the effectiveness of the stimulation through StiMote.

引用

页码：1110 / 1122

页数：13