The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring

被引：31

作者：

Batool, Syeda Maheen ^{[1
]}

Yekula, Anudeep ^{[1
]}

Khanna, Prerna ^{[1
]}

Hsia, Tiffaney ^{[1
]}

Gamblin, Austin S. ^{[1
]}

Ekanayake, Emil ^{[1
]}

Escobedo, Ana K. ^{[1
]}

You, Dong Gil ^{[1
]}

Castro, Cesar M. ^{[1
]}

Im, Hyungsoon ^{[1
]}

Kilic, Tugba ^{[1
]}

Garlin, Michelle Andrea ^{[1
]}

Skog, Johan ^{[2
]}

Dinulescu, Daniela M. ^{[3
]}

Dudley, Jonathan ^{[4
]}

Agrawal, Nishant ^{[5
]}

Cheng, Jordan ^{[6
]}

Abtin, Fereidoun ^{[6
]}

Aberle, Denise R. ^{[6
]}

Chia, David ^{[6
]}

Elashoff, David ^{[6
]}

Grognan, Tristan ^{[6
]}

Krysan, Kostyantyn ^{[6
]}

Oh, Scott S. ^{[6
]}

Strom, Charles ^{[6
]}

Tu, Michael ^{[15
]}

Wei, Fang ^{[6
]}

Xian, Rena R. ^{[4
]}

Skates, Steven J. ^{[1
]}

Zhang, David Y. ^{[7
]}

Trinh, Thi ^{[8
]}

Watson, Mark ^{[9
]}

Aft, Rebecca ^{[9
]}

Rawal, Siddarth ^{[9
,10
]}

Agarwal, Ashutosh ^{[11
]}

Kesmodel, Susan B. ^{[11
]}

Yang, Changhuei ^{[12
]}

Shen, Cheng ^{[12
]}

Hochberg, Fred H. ^{[13
]}

Wong, David T. W. ^{[6
]}

Patel, Abhijit A. ^{[8
]}

Papadopoulos, Nickolas ^{[4
]}

Bettegowda, Chetan ^{[4
]}

Cote, Richard J. ^{[9
,10
]}

Srivastava, Sudhir ^{[14
]}

Lee, Hakho ^{[1
]}

Carter, Bob S. ^{[1
]}

Balaj, Leonora ^{[1
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02129 USA

[2] Exosome Diagnost Inc, Waltham, MA USA

[3] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA

[4] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[5] Univ Chicago, Pritzker Sch Med, Chicago, IL USA

[6] Univ Calif Los Angeles, Los Angeles, CA USA

[7] Rice Univ, Houston, TX USA

[8] Yale Univ, Sch Med, New Haven, CT USA

[9] Washington Univ, Sch Med, St Louis, MO USA

[10] Circulogix Inc, St Louis, MO USA

[11] Univ Miami, Miami, FL USA

[12] CALTECH, Pasadena, CA USA

[13] Scintillon Inst, La Jolla, CA USA

[14] NCI, Canc Biomarkers Res Grp, Div Canc Prevent, Bethesda, MD USA

[15] Liquid Diagnost LLC, Los Angeles, CA USA

来源：

CELL REPORTS MEDICINE | 2023年 / 4卷 / 10期

关键词：

CIRCULATING TUMOR-CELLS; LUNG-CANCER; FREE DNA; EXTRACELLULAR VESICLES; DIAGNOSTIC BIOMARKERS; COMPUTED-TOMOGRAPHY; COLORECTAL-CANCER; PERIPHERAL-BLOOD; OVARIAN-CANCER; SERUM DNA;

D O I：

10.1016/j.xcrm.2023.101198

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The emerging field of liquid biopsy stands at the forefront of novel diagnostic strategies for cancer and other diseases. Liquid biopsy allows minimally invasive molecular characterization of cancers for diagnosis, patient stratification to therapy, and longitudinal monitoring. Liquid biopsy strategies include detection and monitoring of circulating tumor cells, cell-free DNA, and extracellular vesicles. In this review, we address the current understanding and the role of existing liquid-biopsy-based modalities in cancer diagnostics and monitoring. We specifically focus on the technical and clinical challenges associated with liquid biopsy and biomarker development being addressed by the Liquid Biopsy Consortium, established through the National Cancer Institute. The Liquid Biopsy Consortium has developed new methods/assays and validated existing methods/technologies to capture and characterize tumor-derived circulating cargo, as well as addressed existing challenges and provided recommendations for advancing biomarker assays.

引用

页数：12

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