Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database

被引：3

作者：

Panzuto, Francesco ^{[1
]}

Partelli, Stefano ^{[2
]}

Campana, Davide ^{[3
]}

de Braud, Filippo ^{[4
]}

Spada, Francesca ^{[5
]}

Cives, Mauro ^{[6
]}

Tafuto, Salvatore ^{[7
]}

Bertuzzi, Alexia ^{[8
]}

Gelsomino, Fabio ^{[9
]}

Bergamo, Francesca ^{[10
]}

Marcucci, Stefano ^{[11
]}

Mastrangelo, Laura ^{[12
]}

Massironi, Sara ^{[13
]}

Appetecchia, Marialuisa ^{[14
]}

Filice, Angelina ^{[15
]}

Badalamenti, Giuseppe ^{[16
]}

Bartolomei, Mirco ^{[17
]}

Amoroso, Vito ^{[18
]}

Landoni, Luca ^{[19
]}

Rodriquenz, Maria Grazia ^{[20
]}

Valente, Monica ^{[21
]}

Colao, Annamaria ^{[22
]}

Isidori, Andrea ^{[23
]}

Fanciulli, Giuseppe ^{[24
]}

Bollina, Roberto ^{[25
]}

Ciola, Michele ^{[26
]}

Butturini, Giovanni ^{[27
]}

Marconcini, Riccardo ^{[28
]}

Arvat, Emanuela ^{[29
]}

Cinieri, Saverio ^{[30
]}

Berardi, Rossana ^{[31
]}

Baldari, Sergio ^{[32
]}

Riccardi, Ferdinando ^{[33
]}

Spoto, Chiara ^{[34
]}

Giuffrida, Dario ^{[35
]}

Gattuso, Domenico ^{[36
]}

Ferone, Diego ^{[37
]}

Rinzivillo, Maria ^{[1
]}

Bertani, Emilio ^{[38
]}

Versari, Annibale ^{[15
]}

Zerbi, Alessandro ^{[39
]}

Lamberti, Giuseppe ^{[3
]}

Lauricella, Eleonora ^{[6
]}

Pusceddu, Sara ^{[4
]}

Fazio, Nicola ^{[5
]}

Dell'Unto, Elisabetta ^{[1
]}

Marini, Marco ^{[40
]}

Falconi, Massimo ^{[2
]}

机构：

[1] Sapienza Univ Rome, St Andrea Univ Hosp, ENETS Ctr Excellence, Dept Med Surg Sci & Translat Med,Digest Dis Unit, Rome, Italy

[2] Univ Vita Salute San Raffaele, Pancreat Surg Unit, ENETS Ctr Excellence, Pancreas Translat & Clin Res Ctr, Milan, Italy

[3] Alma Mater Studiorum Bologna Univ, Dept Med & Surg Sci DIMEC, Radiat Oncol, Bologna, Italy

[4] Fdn IRCCS Ist Nazl Tumori Milano, ENETS Ctr Excellence, Dept Med Oncol, Milan, Italy

[5] European Inst Oncol IEO, Unit Gastrointestinal & Neuroendocrine Tumors, Milan, Italy

[6] Univ Bari Aldo Moro, Dipartimento Interdisciplinare Med, Bari, Italy

[7] IRCCS, ENETS Ctr Excellence, Ist Nazl Tumori Fdn G Pascale, I-80131 Naples, Italy

[8] IRCCS Humanitas Res Hosp, Hematol & Oncol, Via Manzoni 56, I-20089 Milan, Italy

[9] Univ Hosp Modena, Dept Oncol & Hematol, Div Oncol, Modena, Italy

[10] IRCCS, Veneto Inst Oncol IOV, Oncol 1, Padua, Italy

[11] St Chiara Hosp, Gastroenterol & Digest Endoscopy Unit, Azienda Provinciale & Servizi Sanit APSS, Largo Medaglie Oro 9, I-38122 Trento, Italy

[12] Univ Bologna, Fac Ingn, Bologna, Italy

[13] Univ Milano Bicocca, Fdn IRCCS San Gerardo Tintori, Sch Med, Div Gastroenterol, I-20900 Monza, Italy

[14] Natl Inst Canc Regina Elena, Endocrinol Unit, Rome, Italy

[15] Azienda USL IRCCS Reggio Emilia, Dept Med, Reggio Emilia, Italy

[16] Univ Palermo, Dept Surg Oncol & Oral Sci, Palermo, Italy

[17] Nucl Med Unit, Ferrara, Italy

[18] Univ Brescia, Dept Med & Surg Specialties, Med Oncol Unit, Radiol Sci & Publ Hlth,ASST Spedali Civili, Brescia, Italy

[19] Univ & Hosp Trust Verona, ENETS Ctr Excellence, Pancreas Inst, Dept Surg, Verona, Italy

[20] IRCCS, Geriatr Unit, Casa Sollievo Sofferenza, San Giovanni Rotondo, Foggia, Italy

[21] Univ Hosp Siena, Ctr Immuno Oncol, Oncol, Siena, Italy

[22] Univ Federico II, Dept Clin Med & Surg, Naples ENETS Ctr Excellence, Naples, Italy

[23] Sapienza Univ Rome, Dept Expt Med, Rome, Italy

[24] Endocrine Unit, Azienda Osped Univ AOU Sassari, Sassari, Italy

[25] ASST Rhodense, Presidio Rho, Milan, Italy

[26] Reg Hosp Bolzano, Bolzano, Italy

[27] P Pederzoli Hosp, Div Cardiol, Peschiera Del Garda, Italy

[28] Azienda Ospedaliero Universitaria Pisana, Unit Med Oncol 2, Pisa, Italy

[29] Univ Turin, Dept Med Sci, Oncol Endocrinol Unit, Turin, Italy

[30] A Perrino Hosp, Oncol Unit, Brindisi, Italy

[31] Univ Politecn Marche, AOU Ospedali Riuniti, Dept Med Oncol, Ancona, Italy

[32] Univ Messina, Dept Biomed & Dent Sci & Morpho Funct Imaging, Nucl Med Unit, Messina, Italy

[33] Osped Cardarelli, Med Oncol Unit, Naples, Italy

[34] St Maria Goretti Hosp, Dept Diagnost & Intervent Radiol, Latina, Italy

[35] Ist Oncol Mediterraneo Ricerca Viagrande, Catania, Italy

[36] S Filippo Neri Hosp ASL Roma 1, Neurol Unit, Rome, Italy

[37] Univ Genoa, IRCCS Osped Policlin San Martino, Dept Internal Med & Med Specialties DiMI, Endocrinol Unit, Genoa, Italy

[38] European Canc Inst IEO, ENETS Ctr Excellence, Oncol Unit, Milan, Italy

[39] Humanitas Univ, IRCCS Humanitas Res Hosp, Dept Biomed Sci, Pieve Emanuele, Italy

[40] IMT Sch Adv Studies Lucca, Lucca, Italy

来源：

ENDOCRINE | 2024年 / 84卷 / 01期

关键词：

Neuroendocrine tumors; epidemiology; registry; management; database; STAGE;

D O I：

10.1007/s12020-023-03649-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neuroendocrine neoplasms (NENs) are rare tumors with diverse clinical behaviors. Large databases like the Surveillance, Epidemiology, and End Results (SEER) program and national NEN registries have provided significant epidemiological knowledge, but they have limitations given the recent advancements in NEN diagnostics and treatments. For instance, newer imaging techniques and therapies have revolutionized NEN management, rendering older data less representative. Additionally, crucial parameters, like the Ki67 index, are missing from many databases. Acknowledging these gaps, the Italian Association for Neuroendocrine Tumors (Itanet) initiated a national multicenter prospective database in 2019, aiming to gather data on newly-diagnosed gastroenteropancreatic neuroendocrine (GEP) NENs. This observational study, coordinated by Itanet, includes patients from 37 Italian centers. The database, which is rigorously maintained and updated, focuses on diverse parameters including age, diagnostic techniques, tumor stage, treatments, and survival metrics. As of October 2023, data from 1,600 patients have been recorded, with an anticipation of reaching 3600 by the end of 2025. This study aims at understanding the epidemiology, clinical attributes, and treatment strategies for GEP-NENs in Italy, and to introduce the Itanet database project. Once comprehensive follow-up data will be acquired, the goal will be to discern predictors of treatment outcomes and disease prognosis. The Itanet database will offer an unparalleled, updated perspective on GEP-NENs, addressing the limitations of older databases and aiding in optimizing patient care.

引用

页码：42 / 47

页数：6

共 6 条

[1] Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database
Francesco Panzuto
Stefano Partelli
Davide Campana
Filippo de Braud
Francesca Spada
Mauro Cives
Salvatore Tafuto
Alexia Bertuzzi
Fabio Gelsomino
Francesca Bergamo
Stefano Marcucci
Laura Mastrangelo
Sara Massironi
Marialuisa Appetecchia
Angelina Filice
Giuseppe Badalamenti
Mirco Bartolomei
Vito Amoroso
Luca Landoni
Maria Grazia Rodriquenz
Monica Valente
Annamaria Colao
Andrea Isidori
Giuseppe Fanciulli
Roberto Bollina
Michele Ciola
Giovanni Butturini
Riccardo Marconcini
Emanuela Arvat
Saverio Cinieri
Rossana Berardi
Sergio Baldari
Ferdinando Riccardi
Chiara Spoto
Dario Giuffrida
Domenico Gattuso
Diego Ferone
Maria Rinzivillo
Emilio Bertani
Annibale Versari
Alessandro Zerbi
Giuseppe Lamberti
Eleonora Lauricella
Sara Pusceddu
Nicola Fazio
Elisabetta Dell’Unto
Marco Marini
Massimo Falconi
Endocrine, 2024, 84 : 42 - 47
[2] A Systematic Review of the Classification of Gastroenteropancreatic Neuroendocrine Tumors in Studies that Utilize the Surveillance, Epidemiology, and End Results Program and the National Cancer Database
Hanson, Theo
Hua, Margaret
Chilukuri, Shreya
Rodriguez, Jorge
Hammill, Chet
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2023, 237 (05) : S466 - S467
[3] Epidemiology, Pathological Features and Clinical Outcome of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs): Results from the National Neuroendocrine Cancer Registry of Spain (R-GETNE)
Jimenez-Fonseca, P.
Capdevila, J.
Alonso Orduna, V
Fernandez Medina, I
Teule Vega, A.
Marazuela Azpiroz, M.
Beguiristain Gomez, A.
Llanos Munoz, M.
Martinez del Prado, M.
Sevilla Garcia, M.
Carmona-Bayonas, A.
Castellano, D.
Diaz Perez, J.
Castano, A.
Garcia Carbonero, R.
NEUROENDOCRINOLOGY, 2016, 103 : 17 - 17
[4] The Role of Chemotherapy in the Management of Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs): The Large Experience of the Spanish National Tumor Registry (RGETNE)
Garcia-Carbonero, R.
Capdevila, J.
Jimenez-Fonseca, P.
Alonso, V
Pachon, V
Sevilla, I
Sastre, J.
Llanos, M.
Castano, A.
Salazar, R.
NEUROENDOCRINOLOGY, 2012, 96 : 31 - 32
[5] Exploring the Rising Incidence of Gastroenteropancreatic Neuroendocrine Tumors According to the Data from Regional Cancer Registry: A Population-Based Analysis of Epidemiology
Vladova, P.
Popovska, S.
Iliev, S.
Tonchev, P.
NEUROENDOCRINOLOGY, 2016, 103 : 20 - 20
[6] A SYSTEMATIC REVIEW OF THE CLASSIFICATION OF GASTROINTESTINAL TRACT NEUROENDOCRINE NEOPLASMS IN STUDIES THAT UTILISE THE SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS PROGRAM AND THE NATIONAL CANCER DATABASE
Hanson, T.
Hua, M.
Yaeger, L.
JZ, Rodriguez
Hammill, C.
IRISH JOURNAL OF MEDICAL SCIENCE, 2023, 192 (SUPPL 1) : S26 - S27

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