A Nickel(II) Chloride and Tetrahydroxydiboron Cocatalyzed Facile Synthesis of Benzo[b]azepines with an Appended Fluorinated Side Chain

被引：0
|
作者：
Lei, Wenqing [1 ]
Yang, Yingfan [1 ]
Guo, Minjie [2 ]
Zhao, Wentao [1 ]
Wang, Guangwei [1 ]
机构：
[1] Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Dept Chem, Sch Sci, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Inst Mol Design & Synth, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2023年 / 55卷 / 17期
基金：
中国国家自然科学基金;
关键词：
tetrahydroxydiboron; ethyl bromodifluoroacetate; nickel catalyst; radical cascade; benzo[b]azepines; RADICAL CYCLIZATION; DIFLUOROALKYLATION; PHARMACEUTICALS; 1-BENZAZEPINES; IMIPRAMINE; SCAFFOLDS;
D O I：
10.1055/a-2096-7045
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel nickel-catalyzed chemoselective cascade reaction strategy towards the synthesis of benzo[b]azepines was developed. The method is characterized by simple and mild conditions, low cost, and a wide range of substrates. This method enabled the facile and efficient synthesis of a series of 2,3,4,5-tetrahydro-1H-benzo[b]azepine analogues with an appended fluorinated side chain.
引用
收藏
页码：2702 / 2712
页数：11
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